{"product_id":"biolegend-306102","title":"Biolegend, 306102, Purified anti-human CD131 Antibody, 100μg","description":"\u003cp\u003eCD131, also known as the IL-3R common β subunit (β C ), is a 95-120 kD type I transmembrane glycoprotein and belongs to the Ig superfamily. The common β subunit associates with the specific α subunits of IL-3 receptor, IL-5 receptor and GM-CSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth\/activation of eosinophils and in the inflammatory response. The 1C1 antibody is a non-blocking antibody.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human IL-3R β chain transfected COS cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP, WB - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting1,2 and immunoprecipitation2. The 1C1 antibody does not block binding of IL-3 and is a non-neutralizing antibody.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Stomski F, et al. 1998. J. Biol. Chem. 273:1192. (WB) Stomski F, et al. 1999. Blood 94:1933. (IP WB) Mark A, et al. 2000. Mol. Cell 6:99.\u003cbr\u003e\nRRID: AB_2229992 (BioLegend Cat. No. 306102)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, associates with the α subunit of IL-3, IL-5, GM-CSF receptors, 95-120 kD\u003cbr\u003e\nDistribution: Low levels on monocytes, granulocytes, eosinophils, basophils, hematopoietic progenitors, endothelial cells\u003cbr\u003e\nFunction: Signal transducing molecule of IL-3, IL-5, GM-CSF receptors\u003cbr\u003e\nLigand\/Receptor: IL-3, IL-5, GM-CSF\u003cbr\u003e\nCell Type: Basophils, Endothelial cells, Eosinophils, Granulocytes, Hematopoietic stem and progenitors, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Sun Q, et al. 1999. Blood 94:1943. 2. Woodcock J, et al. 1997. Blood 90:3005. 3. Lopez A, et al. 1991. J. Biol. Chem. 266:24741.\u003cbr\u003e\nGene ID: 1439\u003cbr\u003e\nUniProt: View information about CD131 on UniProt.org\u003cbr\u003e\nClone: 1C1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-3R common β chain, CDw131\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860847284393,"sku":"306102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-306102","provider":"Iright","version":"1.0","type":"link"}