{"product_id":"biolegend-313302","title":"Biolegend, 313302, Purified anti-human CD135 (Flt-3\/Flk-2) Antibody, 100μg","description":"\u003cp\u003eCD135 is a 130-160 kD type III tyrosine kinase receptor expressed on CD34 + hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: BV-173 pro-B cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed Baskar R, et al. 2022. Cell Rep Methods. 2:. PubMed Crawford LB, et al. 2021. J Virol. 95:. PubMed Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed\u003cbr\u003e\nRRID: AB_314987 (BioLegend Cat. No. 313302)\u003cbr\u003e\nStructure: Member of the immunoglobulin supergene family, type 3 tyrosine kinase receptor; 130-160 kD\u003cbr\u003e\nDistribution: Expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. Also expressed on AML, ALL and CML-BC tumor cells\u003cbr\u003e\nFunction: Tyrosine kinase growth factor receptor involved in the growth and differentiation of primitive hematopoietic cells\u003cbr\u003e\nLigand\/Receptor: FLT3 ligand\u003cbr\u003e\nCell Type: B cells, Hematopoietic stem and progenitors, Leukemia, Thymocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Rappold I, et al. 1997. Blood 90:111. 2. Rosnet O, et al. 1996. Acta Haematol. 95:218. 3. Rosnet O, et al. 1996. Leukemia 10:238. 4. Bertho JM, et al. 2000. Scand. J. Immunol. 52:53.\u003cbr\u003e\nGene ID: 2322\u003cbr\u003e\nUniProt: View information about CD135 on UniProt.org\u003cbr\u003e\nClone: BV10A4H2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FMS-like tyrosine kinase-3, FLT-3, STK-1, Flk-2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862926643369,"sku":"313302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-313302","provider":"Iright","version":"1.0","type":"link"}