{"product_id":"biolegend-315107","title":"Biolegend, 315107, Purified anti-human CD39 Antibody, 100μg","description":"\u003cp\u003eHuman CD39 is an integral membrane protein with two transmembrane domains. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector\/memory-like. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ectonucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CD39 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunocytochemistry, a concentration range of 1.0 - 2.5 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_3683330 (BioLegend Cat. No. 315107)\u003cbr\u003e\nStructure: Multi-pass membrane protein\u003cbr\u003e\nDistribution: Plasma membrane, Caveola\u003cbr\u003e\nFunction: ATP hydrolysis, ATP binding, Hydrolase\u003cbr\u003e\nInteraction: Activated lymphocytes\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Lymphocytes, T cells, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Maliszewski CR, et al. 1994. J Immunol. 153:3574-3583. Kaczmarek E, et al. 1996. J Biol Chem. 271:33116-33122. Jiang X, et al. 2023. Front Immunol. 14:1110325-1110325. Timperi E, et al. 2021. Int J Mol Sci. 22:8068-8068. Mitra A, et al. 2023. Clin Cancer Res. 29:4242-4255.\u003cbr\u003e\nGene ID: 953\u003cbr\u003e\nUniProt: View information about CD39 on UniProt.org\u003cbr\u003e\nClone: S23003F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ENTPD1, ATPDase, NTPDase-1, SPG64, ectonucleoside triphosphate diphosphohydrolase 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866278514857,"sku":"315107","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-315107","provider":"Iright","version":"1.0","type":"link"}