{"product_id":"biolegend-315602","title":"Biolegend, 315602, Purified anti-human CD98 Antibody, 100μg","description":"\u003cp\u003eCD98 is a 125 kD disulfide-linked heterodimer protein also known as 4F2 and FRP-1. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis. The MEM-108 antibody is useful for flow cytometry and immunoprecipitation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Burkitt's lymphoma cell line Raji\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality testedIP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. New York. Cantor J, et al. 2011. J. Immunol. 187:851. PubMed.\u003cbr\u003e\nProduct Citations: Weng L, et al. 2018. PLoS Biol. 7:e1428158. PubMed Dhawan K, et al. 2022. Mol Biol Cell. 33:ar107. PubMed Feliciano D, et al. 2021. Nat Commun. 12:4502. PubMed Wunderley L, et al. 2021. J Cell Sci. . PubMed Wunderley L, et al. 2021. J Cell Sci. 134:. PubMed Higashi S, et al. 2022. J Cell Sci. 135:. PubMed Arndt C, et al. 2020. Oncoimmunology. 9:1743036. PubMed Cantor J, et al. 2011. J Immunol. 187:851. PubMed\u003cbr\u003e\nRRID: AB_2302070 (BioLegend Cat. No. 315602)\u003cbr\u003e\nStructure: Disulfide-linked heterodimer, 80 kD and 45 kD reduced, 125 kD unreduced\u003cbr\u003e\nDistribution: Broadly expressed on activated and transformed cells, not hematopoietic cell-specific. Lower levels on resting cells\u003cbr\u003e\nFunction: Potential amino acid transporter (neutral and dibasic amino acids) also involved in the activation of lymphocytes and integrin signaling. May be a target antigen for NK cells\u003cbr\u003e\nInteraction: Actin, β1 integrins (α2β1, α3β1, α5β1, α6β1; minimally with α4β1)\u003cbr\u003e\nModification: Glycosylated (heavy chain)\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Leukocyte Typing VI. Kishimoto T, et al. (Eds.) Garland Publishing Inc. (1997) 2. Bron C, et al. 1986. J. Immunol. 137:397. 3. Lumadue JA, et al. 1987. Proc. Natl. Acad. Sci. 84:9204. 4. Mastroberardino L, et al. 1998. Nature 395:288.\u003cbr\u003e\nGene ID: 6520\u003cbr\u003e\nUniProt: View information about CD98 on UniProt.org\u003cbr\u003e\nClone: MEM-108\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 4F2, FRP-1, RL-388\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866462474409,"sku":"315602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-315602","provider":"Iright","version":"1.0","type":"link"}