{"product_id":"biolegend-316901","title":"Biolegend, 316901, Purified anti-human CD268 (BAFF-R) Antibody, 25μg","description":"\u003cp\u003eB cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF\/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: BAFF-R-L1.2 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC) Personal communication. (Block)\u003cbr\u003e\nRRID: AB_528985 (BioLegend Cat. No. 316902)\u003cbr\u003e\nStructure: Type III transmembrane protein, TNF receptor superfamily, 19 kD\u003cbr\u003e\nDistribution: Mature B cells, B cell lymphoma, T cell subset\u003cbr\u003e\nFunction: Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation\u003cbr\u003e\nLigand\/Receptor: BAFF\/BLys, associate with TRAF3\u003cbr\u003e\nCell Type: B cells, Leukemia, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Thompson JS, et al. 2001. Science 293:2108. 2. Ng LG, et al.2004. J. Immunol. 173:807. 3. Rodig SJ, et al. 2005. Human Pathol. 36:1113. 4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750. 5. Kayagaki N, et al. 2002 Immunity 17:515.\u003cbr\u003e\nGene ID: 115650\u003cbr\u003e\nUniProt: View information about CD268 on UniProt.org\u003cbr\u003e\nClone: 11C1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860791939241,"sku":"316901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-316901","provider":"Iright","version":"1.0","type":"link"}