{"product_id":"biolegend-316914","title":"Biolegend, 316914, Alexa Fluor® 647 anti-human CD268 (BAFF-R, BAFFR) Antibody, 100tests","description":"\u003cp\u003eB cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF\/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: BAFF-R-L1.2 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm \/ 635nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC) Personal communication. (Block)\u003cbr\u003e\nProduct Citations: Kamburova E, et al. 2012. Am J Transplant. 12:341. PubMed Wejksza K, et al. 2013. J Immunol. 190:2575. PubMed\u003cbr\u003e\nRRID: AB_2203680 (BioLegend Cat. No. 316914)\u003cbr\u003e\nStructure: Type III transmembrane protein, TNF receptor superfamily, 19 kD\u003cbr\u003e\nDistribution: Mature B cells, B cell lymphoma, T cell subset\u003cbr\u003e\nFunction: Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation\u003cbr\u003e\nLigand\/Receptor: BAFF\/BLys, associate with TRAF3\u003cbr\u003e\nCell Type: B cells, Leukemia, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Thompson JS, et al. 2001. Science 293:2108. 2. Ng LG, et al.2004. J. Immunol. 173:807. 3. Rodig SJ, et al. 2005. Human Pathol. 36:1113. 4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750. 5. Kayagaki N, et al. 2002 Immunity 17:515.\u003cbr\u003e\nGene ID: 115650\u003cbr\u003e\nUniProt: View information about CD268 on UniProt.org\u003cbr\u003e\nClone: 11C1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860792168617,"sku":"316914","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-316914","provider":"Iright","version":"1.0","type":"link"}