{"product_id":"biolegend-317012","title":"Biolegend, 317012, Purified anti-human CD4 Recombinant Antibody, 100μg","description":"\u003cp\u003eCD4, also known as T4\/Leu-3, is a 55 kD single-chain type I transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed on most thymocytes, helper T cells, type II NKT cells, and monocytes\/macrophages. CD4 is part of the TCR\/CD3 complex, binds to β2 domain from the MHC class II molecule, and participates in TCR signal transduction. CD4 is the receptor of IL-16 and is a coreceptor for the human immunodeficiency virus (HIV) and human herpes virus 7 (HHV-7).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A161A1.RecM1 can completely block the binding of clone A161A1 on target cells.\u003cbr\u003e\nRRID: AB_3698974 (BioLegend Cat. No. 317012)\u003cbr\u003e\nStructure: 55 kD, type I transmembrane glycoprotein, member of the Ig superfamily\u003cbr\u003e\nDistribution: Helper T cells, majority of thymocytes, monocytes\/macrophages, type II NKT cells\u003cbr\u003e\nInteraction: TCR\/CD3 complex, LCK\u003cbr\u003e\nLigand\/Receptor: MHC class II molecules\u003cbr\u003e\nCell Type: Lymphocytes, Macrophages, Monocytes, NKT cells, T cells, Tfh, Th1, Th17, Th2, Thymocytes, Tregs\u003cbr\u003e\nBiology Area: Adaptive Immunity, Cell Adhesion, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Sattentau QK and Weiss RA. 1988. Cell. 52:631-3. Littman DR, et al. 1987. Annu Rev Immunol. 5:561-84. Zhu J, et al. 2010. Annu Rev Immunol. 28:445-89. Vignali DA. 2010. J Immunol. 184:5933-4.\u003cbr\u003e\nGene ID: 920\u003cbr\u003e\nUniProt: View information about CD4 on UniProt.org\u003cbr\u003e\nClone: A161A1.RecM1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T4\/Leu-3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864403202217,"sku":"317012","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-317012","provider":"Iright","version":"1.0","type":"link"}