{"product_id":"biolegend-318306","title":"Biolegend, 318306, PE anti-human CD56 (NCAM) Antibody, 100tests","description":"\u003cp\u003eCD56 is a single transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule), Leu-19, or NKH1. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK cells and NK-T cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone HCD56 is not recommended for immunohistochemistry formalin-fixed paraffin-embedded tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed\u003cbr\u003e\nProduct Citations: Toepfner N et al. 2018. eLife. 7 pii: e29213. PubMed Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed Brusilovsky M, et al. 2013. J Immunol. 191:5256. PubMed Li H, et al. 2018. PLoS Genet. 14:e1007163. PubMed Andonian BJ, et al. 2022. Sci Rep. 12:7450. PubMed Junker F, et al. 2021. Cytometry A. 99:832. PubMed Abbas Y, et al. 2017. Journal of the Royal Society Interface. 10.1098\/rsif.2017.0131. PubMed Mastelic-Gavillet B, et al. 2019. J Immunother Cancer. 7:257. PubMed Zhao Y, et al. 2021. Front Immunol. 12:665442. PubMed Armour K, et al. 2014. PLoS One. 9:109463. PubMed Esaulova E, et al. 2020. Cell Host Microbe. 29(2):165-178.e8. PubMed Seamon K, et al. 2020. Front Immunol. 11:396. PubMed Song C, et al. 2022. Stem Cell Res Ther. 13:48. PubMed Leem G, et al. 2021. J Allergy Clin Immunol. 148:996. PubMed Gajdasik DW, et al. 2020. Nat Commun. 2.834027778. PubMed Fionda C, et al. 2009. J Immunol. 183:4385. PubMed Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed Zirngibl F, et al. 2021. J Immunother Cancer. 9:. PubMed Torres-Ruiz J, et al. 2021. Front Immunol. 12:689966. PubMed Sandström N, et al. 2022. Cell Rep Methods. 2:100256. PubMed Hsu H, et al. 2016. J Immunol. 197: 1884 - 1892. PubMed Yin W, et al. 2021. Thorac Cancer. 12:2680. PubMed Kuo HH, et al. 2018. Immunity. 48:1183. PubMed Walk J, et al. 2020. Front Immunol. 2.405555556. PubMed Woodberry T, et al. 2017. Infect Immun. 85:e00986. PubMed Gawel DR, et al. 2019. Genome Med. 11:47. PubMed Le J, et al. 2020. Immunity. 52(6):1105-1118.e9. PubMed Dangaj D, et al. 2019. Cancer Cell. 35:885. PubMed Lundell A, et al. 2017. Sci Rep. 7:39904. PubMed Elias S, et al. 2020. Haematologica. . PubMed Salvany‐Celades M et al. 2019. Cell Rep. 27(9):2537-2547 . PubMed Yu H, et al. 2021. Cell Death Dis. 13:1. PubMed van Erp EA, et al. 2020. Clin Transl Immunology. 9:e1112. PubMed Warthan MD, et al. 2018. Biol Reprod. 98:309. PubMed Obiero J, et al. 2015. Infect Immun . 83:2185. PubMed Fernandez IZ, et al. 2019. J Exp Med. 216:1255. PubMed Dzhumashev D, et al. 2022. Cancers (Basel). 14:. PubMed Aram J, et al. 2020. Biomedicines. 8:. PubMed\u003cbr\u003e\nRRID: AB_604093 (BioLegend Cat. No. 318305) AB_604101 (BioLegend Cat. No. 318306)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparin sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lanier L, et al. 1991. J. Immunol. 146:4421. 2. Hemperly J, et al. 1990. J. Mol. Neurosci. 2:71. 3. Cremer H, et al. 1994. Nature 367:455.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: HCD56\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866454151337,"sku":"318306","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-318306","provider":"Iright","version":"1.0","type":"link"}