{"product_id":"biolegend-321507","title":"Biolegend, 321507, Purified anti-human FcRn Antibody, 100μg","description":"\u003cp\u003eFcRn is a 43 kD transmembrane MHC class I-like glycoprotein. It forms the neonatal Fc receptor through a non-covalent association with β2-microglobulin. FcRn is expressed in the vascular endothelium, blood-brain barrier, kidney, and several leukocyte subsets, including monocytes, neutrophils, and dendritic cells. In association with β2-microglobulin, FcRn binds to human IgG, and transports maternal antibodies to the fetus antenatally across the placenta. In adults, FcRn plays a crucial role in extending the half-lives of IgG and albumin by recycling and preventing them from degradation. Additionally, FcRn can promote antigen presentation by enhancing IgG-mediated phagocytosis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human FcRn transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested FC, Block - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For intracellular flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. For surface flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S23035A can block the binding of human IgG to cell surface FcRn. Clone S23035A can detect FcRn on cell surface and intracellularly.\u003cbr\u003e\nRRID: AB_3720493 (BioLegend Cat. No. 321507)\u003cbr\u003e\nStructure: Transmembrane MHC class I-like glycoprotein, 43 kD\u003cbr\u003e\nDistribution: Monocytes, neutrophils, and dendritic cells\u003cbr\u003e\nFunction: Transport IgG across cell membrane, recycling IgG and extending its half-life in the circulation\u003cbr\u003e\nLigand\/Receptor: Human IgG\u003cbr\u003e\nCell Type: Antigen-presenting cells, B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Adaptive Immunity, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Fc Receptors\u003cbr\u003e\nAntigen References: Story CM, et al. 1994. J Exp Med. 2377-81. Kandil E, et al. 1996. Cytogenet Cell Genet. 73: 97–8.\u003cbr\u003e\nGene ID: 2217\u003cbr\u003e\nUniProt: View information about FcRn on UniProt.org\u003cbr\u003e\nClone: S23035A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IgG Fc fragment receptor transporter alpha chain, FcgammaRn alpha-chain, Neonatal Fc receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866279268521,"sku":"321507","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-321507","provider":"Iright","version":"1.0","type":"link"}