{"product_id":"biolegend-327801","title":"Biolegend, 327801, Purified anti-human CD104 Antibody, 25μg","description":"\u003cp\u003eCD104 is a 205 kD type I transmembrane glycoprotein, known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) forms α6\/β4 (CD49f\/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f\/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Sivasubramaniyan K, et al. 2015. Glycobiology. 25: 902-917. PubMed Heesters BA, et al. 2021. J Exp Med. 218:. PubMed\u003cbr\u003e\nRRID: AB_893212 (BioLegend Cat. No. 327802)\u003cbr\u003e\nStructure: Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)\u003cbr\u003e\nDistribution: Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Laminins, keratin filaments\u003cbr\u003e\nCell Type: Epithelial cells, Endothelial cells, T cells, Embryonic Stem Cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Kippenberger S, et al. 2004. J. Invest. Dermatol. 123:444.2. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley \u0026amp; Sons Inc, Publication\u003cbr\u003e\nGene ID: 3691\u003cbr\u003e\nUniProt: View information about CD104 on UniProt.org\u003cbr\u003e\nClone: 58XB4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin β4, β4 integrin, TSP-1180, ITGB4\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864149479593,"sku":"327801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-327801","provider":"Iright","version":"1.0","type":"link"}