{"product_id":"biolegend-328317","title":"Biolegend, 328317, APC\/Fire™ 750 anti-human CD49a Antibody, 25tests","description":"\u003cp\u003eCD49a is a 200 kD type I transmembrane glycoprotein also known as α 1 integrin, VLA-1 α chain, or Integrin α 1 . It associates with CD29 (β 1 integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. It is expressed on activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CTL line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Fire™ 750 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. * APC\/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: immunoprecipitation1, immunohistochemical staining1 of acetone-fixed frozen tissue sections, and spatial biology (IBEX)3,4.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Hemler ME, et al. 1984. J.Immunol. 132:3011 Hemler ME, et al. 1985. J. Biol. Chem. 260:15246 Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Jaiswal A, et al. 2022. Cancer Cell. 40:524. PubMed\u003cbr\u003e\nRRID: AB_2810494 (BioLegend Cat. No. 328317) AB_2810495 (BioLegend Cat. No. 328318)\u003cbr\u003e\nStructure: Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. Associates with CD29 to form VLA-1 complex\u003cbr\u003e\nDistribution: Activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells\u003cbr\u003e\nFunction: Adhesion, leukocyte migration\u003cbr\u003e\nLigand\/Receptor: With integrin β1 (CD29) forms receptor for laminin-1 and collagen IV\u003cbr\u003e\nCell Type: Fibroblasts, Mesenchymal cells, Mesenchymal Stem Cells, Monocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss Press. p122 Boiret N, et al. 2005. Exp. Hematol. 33:219\u003cbr\u003e\nGene ID: 3672\u003cbr\u003e\nUniProt: View information about CD49a on UniProt.org\u003cbr\u003e\nClone: TS2\/7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: α1 integrin, VLA-1 α chain, Integrin α1 chain, ITGA1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864033415337,"sku":"328317","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-328317","provider":"Iright","version":"1.0","type":"link"}