{"product_id":"biolegend-329601","title":"Biolegend, 329601, Purified anti-human CD273 (B7-DC, PD-L2) Antibody, 25μg","description":"\u003cp\u003eCD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human PD-L2 cDNA\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-F, FA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Brown JA, et al. 2003. J. Immunol. 170:1257 Rodig N, et al. 2003. Eur. J. Immunol. 33:3117\u003cbr\u003e\nProduct Citations: Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed Yonemitsu K, et al. 2022. Sci Rep. 12:12007. PubMed Komohara Y, et al. 2018. J Clin Exp Hematop. 58:152. PubMed Heesters BA, et al. 2021. J Exp Med. 218:. PubMed Hoffmann F, et al. 2020. Clin Epigenetics. 12:94. PubMed Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed Garcia de Moura R, et al. 2021. Front Immunol. 12:632667. PubMed Beetz O, et al. 2019. PLoS One. 14:e0220546. PubMed Enyindah-Asonye G, et al. 2019. Front Immunol. 10:511. PubMed\u003cbr\u003e\nRRID: AB_1089010 (BioLegend Cat. No. 329602)\u003cbr\u003e\nStructure: B7 Immunoglobulin superfamily, 25 kD\u003cbr\u003e\nDistribution: Dendritic cells, liver, few transformed cell lines, subset of macrophages\u003cbr\u003e\nFunction: Binds to PD-1 and alternative receptor; ligation on DC stimulates, inhibits T cell responses via PD-1 binding, stimulates T cells via alternative receptor binding and promotes tumor immunity\u003cbr\u003e\nLigand\/Receptor: PD-1\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: 1. Shin T, et al. 2003. J. Exp. Med. 198:31. 2. Liu X, et al. 2003. J. Exp. Med. 197:1721. 3. Carreno BM, et al. 2002. Annu. Rev. Immunol. 20:29.\u003cbr\u003e\nGene ID: 80380\u003cbr\u003e\nUniProt: View information about CD273 on UniProt.org\u003cbr\u003e\nClone: 24F.10C12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-DC, PD-L2, PDL2, B7DC\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860877496489,"sku":"329601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-329601","provider":"Iright","version":"1.0","type":"link"}