{"product_id":"biolegend-331207","title":"Biolegend, 331207, FITC anti-human TCR γ\/δ Antibody, 25tests","description":"\u003cp\u003eT cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α\/β) or a γ and a δ chain (TCR γ\/δ). TCR γ\/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ\/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ\/δ T cells are CD4 - \/CD8 - , some are CD8 + . T cells expressing the γ\/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ\/δ T cells also play a principal role in antigen presentation.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human, Cynomolgus, Rhesus\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Pigtailed Macaque\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Clone B1 is also known as clone B1.1.Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections3 and paraffin-embedded sections5, in vitro blocking, and spatial biology (IBEX)8,9. The Ultra-LEAF™ purified antibody (Endotoxin \u0026lt; 0.01 EU\/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. Nos. 331235 and 331236).\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Rodriguez-Gago M, et al. 2001. Transplantation. 72:503. Lehmann FS, et al. 2002. Am. J. Physiol. Gastrointest. Liver. Physiol. 283:G481. (FC) Bordignon M, et al. 2008. Mol. Med. Rep. 1:485. (IHC) Conrad M, et al. 2007. Cytom. Part A 71A:925. (FC) Pollinger B, et al. 2011. J. Immunol. 186:2602. (IHC) Correia DV, et al. 2011. Blood. 118:992. (Block) Laurent AJ, et al. 2014. PLoS One. 9:103683. PubMed Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Jowett GM, et al. 2022. Cell Rep. 40:111281. PubMed Corral D, et al. 2022. Cell Rep. 39:110715. PubMed Zarobkiewicz M, et al. 2022. J Clin Med. 11: . PubMed McEvoy CM, et al. 2022. Nat Commun. 13:7634. PubMed Galindo-Albarrán A, et al. 2016. Cell Rep. 17:2151-2160. PubMed Park JA, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(5):. PubMed Björklund \u0026amp;, et al. 2016. Nat Immunol. 17:451-460. PubMed Sundström P, et al. 2015. J Immunol. 195: 3472 - 3481. PubMed Hansen IS, et al. 2018. Nat Commun. 9:863. PubMed Wu J, et al. 2021. Front Immunol. 12:601611. PubMed Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed Sefik E, et al. 2021. Nat Biotechnol. . PubMed Hazenberg MD, et al. 2019. Blood Adv. 2.659722222. PubMed Golebski K, et al. 2021. Immunity. 54(2):291-307.e7. PubMed Wang X, et al. 2020. Exp Ther Med. 19:3698. PubMed Singh A, et al. 2020. Cell Rep. 32:108153. PubMed Sasawatari S, et al. 2020. J Immunol. 1373:204. PubMed Okoye AA, et al. 2021. J Clin Invest. 131:. PubMed\u003cbr\u003e\nRRID: AB_1575111 (BioLegend Cat. No. 331207) AB_1575108 (BioLegend Cat. No. 331208)\u003cbr\u003e\nStructure: Ig superfamily, associates with CD3 complex\u003cbr\u003e\nDistribution: T subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum\u003cbr\u003e\nFunction: Antigen recognition\u003cbr\u003e\nLigand\/Receptor: Some bacterial or tumor antigens bound MHC class I, CD1 molecule\u003cbr\u003e\nCell Type: Epithelial cells, T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Lanier LL, et al. 1987. J. Clin. Immunol. 7:429. 2. Spencer J, et al. 1989. Eur. J. Immunol. 19:1335. 3. Uyemura K, et al. 1991. J. Exp. Med. 174:683. 4. Spada FM, et al. 2000. J. Exp. Med. 191:907.\u003cbr\u003e\nGene ID: 69646965\u003cbr\u003e\nUniProt: View information about TCR gamma\/delta on UniProt.org\u003cbr\u003e\nClone: B1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor γ\/δ, γ\/δ TCR, TCR-γ\/δ\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862546501801,"sku":"331207","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-331207","provider":"Iright","version":"1.0","type":"link"}