{"product_id":"biolegend-331317","title":"Biolegend, 331317, Alexa Fluor® 700 anti-human TCR Vγ9 Antibody, 25tests","description":"\u003cp\u003eThe Vγ9 TCR is a variant of the TCR γ chain expressed on a subset of γ\/δ T cells. Vγ9Vδ2 T lymphocytes, a major γ\/δ T cell subset in humans, recognize phosphoantigens, certain tumor cells, and cells treated with aminobisphosphonates. This cell population displays cytolytic activity against various tumor cells. The γ\/δ TCR is a heterodimeric TCR complex composed of covalently bound γ and δ chains involved in antigen recognition and the non-covalently associated monomorphic proteins CD3δ, γ, ε, and ζ chains.  The B3 antibody reacts specifically with human TCR Vγ9 as designated by the Lefranc\/Foster nomenclature system. Human TCR Vγ9 is also known as TCR Vγ2 under the Strauss, Quertermous nomenclature system.  Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the various nomenclature systems, we have created charts for corresponding names across some of the most popular naming methods. Click here to see charts . \u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Chimpanzee, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm \/ 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Van Rhijn I, et al. 2003. Intl. Immunol. 15:373. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)\u003cbr\u003e\nProduct Citations: Bergamaschi L, et al. 2021. Immunity. 54(6):1257-1275.e8. PubMed\u003cbr\u003e\nRRID: AB_2814206 (BioLegend Cat. No. 331317) AB_2814207 (BioLegend Cat. No. 331318)\u003cbr\u003e\nStructure: Ig superfamily member, TCR γ\/δ with CD3 forms the CD3\/TCR complex\u003cbr\u003e\nDistribution: Expressed on majority of peripheral γ\/δ T cells\u003cbr\u003e\nFunction: Antigen recognition, T cell activation\u003cbr\u003e\nLigand\/Receptor: Peptide bound to MHC\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: Scotet E, et al. 2005. Immunity 22:71 Rincon-Orozco B, et al. 2005. J. Immunol. 175:2144\u003cbr\u003e\nGene ID: 6965\u003cbr\u003e\nUniProt: View information about TCR Vgamma9 on UniProt.org\u003cbr\u003e\nClone: B3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor Vγ9, TCR Vγ2 (Strauss, Quertermous nomenclature), TRGV9, TCRGV2S1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862890238121,"sku":"331317","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-331317","provider":"Iright","version":"1.0","type":"link"}