{"product_id":"biolegend-333811","title":"Biolegend, 333811, Alexa Fluor® 488 anti-human CD68 Antibody, 25tests","description":"\u003cp\u003eCD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes\/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported application: immunohistochemical staining of frozen tissue sections. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Doussis IA, et al. 1993. J. Clin. Pathol. 46:334. Davey FR, et al. 1988. J. Clin. Pathol. 41:753. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110. (IF) PubMed\u003cbr\u003e\nProduct Citations: Li M, et al. 2023. Front Immunol. 14:1087923. PubMed Smith MH, et al. 2023. Nat Immunol. . PubMed Zhao P, et al. 2022. MAbs. 14:2107971. PubMed Managò A, et al. 2019. Nat Commun. 10:4116. PubMed McAvoy M, et al. 2020. Front Neurol. 0.905555556. PubMed Ohmatsu H, et al. 2017. Oncoimmunology. 6:e1181237. PubMed Li M, et al. 2020. Nat Commun. 4051:11. PubMed Gage BK, et al. 2020. Cell Stem Cell. 27(2):254-269.e9. PubMed\u003cbr\u003e\nRRID: AB_2074833 (BioLegend Cat. No. 333811) AB_2074832 (BioLegend Cat. No. 333812)\u003cbr\u003e\nStructure: Sialomucin family, 110 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells, granulocytes, subset of hematopoietic progenitors, γ\/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, endothelial cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Hematopoietic stem and progenitors, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Holness CL and Simmons DL. 1993. Blood 81:1607. 2. Gottfried E, et al. 2008. Scand. J. Immunol. 67:453. 3. Hameed A, et al. 1994. Hum. Pathol. 25:872.\u003cbr\u003e\nGene ID: 968\u003cbr\u003e\nUniProt: View information about CD68 on UniProt.org\u003cbr\u003e\nClone: Y1\/82A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR23\u003cbr\u003e\nOther Names: Macrosialin\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864102686889,"sku":"333811","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-333811","provider":"Iright","version":"1.0","type":"link"}