{"product_id":"biolegend-333906","title":"Biolegend, 333906, PE anti-human CD30 Antibody, 100tests","description":"\u003cp\u003eCD30, also known as Ki-1 antigen, lymphoid activation antigen CD30, and tumor necrosis factor receptor superfamily member 8 is a type I transmembrane receptor that contains four TNF receptor domains with an approximate molecular weight of 64 kD. CD30 is highly expressed on Hodgkins and Reed-Sternberg cells as well as activated, but not resting, T and B cells. CD30 has been shown to interact with a number of proteins including TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, and CD30 ligand (CD153). Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CD30 boosted with THP-1 cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported application: in combination with IL-2 and PMA to induce T cell clone proliferation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Leca G, et al. 1994. Cell. Immunol. 156:230.\u003cbr\u003e\nProduct Citations: Lobastova L, et al. 2021. Frontiers in Cell and Developmental Biology. 9:698503. PubMed Dörsam B, et al. 2018. Front Immunol. 7:e34961. PubMed\u003cbr\u003e\nRRID: AB_2207595 (BioLegend Cat. No. 333906)\u003cbr\u003e\nStructure: Type I transmembrane receptor and member of the TNF receptor superfamily that contains 4 TNF receptor domains; predicted molecular weight approximately 64 kD\u003cbr\u003e\nDistribution: Highly expressed on Hodgkins and Reed-Sternberg cells and activated, but not resting, T cells and B cells.\u003cbr\u003e\nFunction: Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.\u003cbr\u003e\nInteraction: TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, CD30 ligand (CD153)\u003cbr\u003e\nLigand\/Receptor: CD30 Ligand (CD153)\u003cbr\u003e\nCell Type: B cells, Embryonic Stem Cells, Tregs\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Durkop H, et al. 1992. Cell 68:421. 2. Aizawa S, et al. 1997. J. Biol. Chem. 272:2042. 3. Stein H, et al. 1982. Int. J. Cancer 30:445.\u003cbr\u003e\nGene ID: 943\u003cbr\u003e\nUniProt: View information about CD30 on UniProt.org\u003cbr\u003e\nClone: BY88\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V BP173\u003cbr\u003e\nOther Names: Ber-H2, Ki-1, TNFRSF8\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862934868137,"sku":"333906","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-333906","provider":"Iright","version":"1.0","type":"link"}