{"product_id":"biolegend-334802","title":"Biolegend, 334802, Purified anti-human CD300c Antibody, 100μg","description":"\u003cp\u003eCD300c, also known as CMRF-35-like molecule 6 (CLM-6) and leukocyte immunoglobulin-like receptor (LIR) is a 25 kD protein that belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes. This transmembrane protein is expressed on certain B cells, T cells, NK cells, granulocytes, macrophages, monocytes, and mast cells. CD300C promotes secretion of proinflammatory cytokines and is an activating immune receptor associated ITAM-bearing adapter DAP12 and FcRγ chain on macrophages.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Simhadri VR, et al. 2013. J. Innate Immun. 4:389.\u003cbr\u003e\nRRID: AB_2303773 (BioLegend Cat. No. 334802)\u003cbr\u003e\nStructure: Ig superfamily, 40 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, dendritic cells\u003cbr\u003e\nFunction: Regulate myeloid cell activation and promote secretion of cytokines and chemokines\u003cbr\u003e\nInteraction: DAP12, FcRγ\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Borrego F. 2013. Blood 11:1951. 2. Ju X, et al. 2009. Immunobiology 730-736. 3. Simhadri, et al. 2011. BMC Immunology 12:62.\u003cbr\u003e\nGene ID: 10871\u003cbr\u003e\nUniProt: View information about CD300c on UniProt.org\u003cbr\u003e\nClone: TX45\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LIR, CLM-6, CMRF35, IGSF16, CMRF-35, CMRF35A, CMRF-35A, CMRF35A1, CMRF35-A1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864059728041,"sku":"334802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-334802","provider":"Iright","version":"1.0","type":"link"}