{"product_id":"biolegend-336408","title":"Biolegend, 336408, Alexa Fluor® 647 anti-human CD61 Antibody, 100tests","description":"\u003cp\u003eCD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41\/CD61 complex and with integrin αV (CD51) to form αV\/β3 (CD51\/CD61) integrin. CD41\/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51\/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Cynomolgus, Rhesus\u003cbr\u003e\nReported Reactivity: African Green, Baboon\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl volume or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm \/ 635nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting and immunohistochemical staining of frozen tissue sections.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Davies J, et al. 1989. J. Cell Biol. 109:1817. Roberts M, et al. 2004. Mol. Cell. Biol. 24:1505. Ciarlet M, et al. 2002. J. Virol. 76:1109.\u003cbr\u003e\nProduct Citations: Garofano K, et al. 2023. Sci Rep. 13:2864. PubMed Zubairova L, et al. 2015. Sci Rep. 5: 17611. PubMed Murray KD, et al. 2021. Front Neurol. 11:595463. PubMed Artemenko E, et al. 2016. Biochem J. 473: 435 - 448. PubMed Singh MV, et al. 2020. J Leukoc Biol. 109:807. PubMed Dieterle ME, et al. 2021. Elife. 10:. PubMed\u003cbr\u003e\nRRID: AB_2128751 (BioLegend Cat. No. 336407) AB_2128750 (BioLegend Cat. No. 336408)\u003cbr\u003e\nStructure: Type I integral glycoprotein, integrin family, associates with CD41 (gpIIb) forming CD41\/CD61 complex or with CD51 (integrin αV) forming CD51\/CD61 complex, 90 kD\u003cbr\u003e\nDistribution: CD41\/CD61 complex is expressed on platelets and megakaryocytes; CD51\/CD61 complex is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells\u003cbr\u003e\nFunction: Adhesion, platelet activation and aggregation\u003cbr\u003e\nLigand\/Receptor: Fibronectin, vitronectin, vWF\u003cbr\u003e\nCell Type: Fibroblasts, Megakaryocytes, Osteoclasts, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers.\u003cbr\u003e\nGene ID: 3690\u003cbr\u003e\nUniProt: View information about CD61 on UniProt.org\u003cbr\u003e\nClone: VI-PL2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Integrin β3, gpIIIa\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864082010281,"sku":"336408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-336408","provider":"Iright","version":"1.0","type":"link"}