{"product_id":"biolegend-336701","title":"Biolegend, 336701, Purified anti-human CD48 Antibody, 25μg","description":"\u003cp\u003eCD48 is a 40-47 kD GPI-anchored membrane protein, also known as Blast-1 and HuLy-m3. It is a member of the CD2 family that contains 2 IgSF domains and is widely expressed on both resting and activated hematopoietic cells with the exception of granulocytes, platelets, and erythrocytes. CD48 binds to CD2 at a considerably (\u0026gt;100-fold) lower affinity than CD58. It is thought to contribute to T cell activation. The cytoplasmic tail of CD48 has been shown to bind to the kinases Lck and Fyn.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, it is recommended to use at ≤ 2.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. 1997. Leucocyte Typing VI:White Cell Differentiation Antigens. Garland Publishing Inc. Wang R, et al. 2012. J. Leukoc Biol. 91:299. PubMed\u003cbr\u003e\nProduct Citations: Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed Dinh HQ, et al. 2020. Immunity. 53(2):319-334.e6. PubMed\u003cbr\u003e\nRRID: AB_1227561 (BioLegend Cat. No. 336702)\u003cbr\u003e\nStructure: CD2 family, contains 2 IgSF domains, GPI-membrane anchored, 40-47 kD\u003cbr\u003e\nDistribution: Widely expressed on hematopoietic cells except granulocytes, platelets, and erythrocytes. Increased on T and B cells after activation\u003cbr\u003e\nFunction: Contributes to T cell antigen recognition\u003cbr\u003e\nLigand\/Receptor: CD2\u003cbr\u003e\nCell Targets: Lck, Fyn interact with cytoplasmic domain\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Fisher RC and Thorley-Lawson DA. 1991. Mol. Cell. Biol. 11:1614. Korinek V, et al. 1991. Immunogenetics 33:108. Leukocyte Typing IV. Knapp W, et al. (Eds) Oxford University Press (1989) Leukocyte Typing V. Schlossman S, et al. (Eds) Oxford University Press (1995)\u003cbr\u003e\nGene ID: 962\u003cbr\u003e\nUniProt: View information about CD48 on UniProt.org\u003cbr\u003e\nClone: BJ40\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Blast-1, SLAMF2, HuLy-m3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862910881961,"sku":"336701","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-336701","provider":"Iright","version":"1.0","type":"link"}