{"product_id":"biolegend-336902","title":"Biolegend, 336902, Purified anti-human CD87 Antibody, 100μg","description":"\u003cp\u003eCD87, known as urokinase plasminogen activator-receptor (uPAR), is a 36-68 kD single-chain glycophosphotidylinositol (GPI)-anchored glycoprotein. The extracellular region of CD87 consists of three homologous domains, D1, D2, and D3. Membrane-bound and soluble (D2D3) forms of uPAR have been reported. The membrane-bound CD87 is expressed on granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. CD87 plays a role in cell adhesion and chemotaxis through binding to β1, β2 and β3 integrins. CD87-bound uPA converts plasminogen to plasmin.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: THP-1 (human myeloid cell line)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications include: VIM5 mAb binds to uPA binding-domain\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Schlossmant SF, et al. eds. 1995 Leukocyte Type V. Oxford University Press Inc, New York Gadd SJ, et al. 1990. Clin. Exp. Immunol 80:252 Sillaber C, et al. 1997. J. Biol. Chem. 272:7824\u003cbr\u003e\nProduct Citations: Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed\u003cbr\u003e\nRRID: AB_2165470 (BioLegend Cat. No. 336902)\u003cbr\u003e\nStructure: Glycophosphotidylinositol (GPI)-anchored glycoprotein, 36-68 kD\u003cbr\u003e\nDistribution: Granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes.\u003cbr\u003e\nFunction: Convert plasminogen to plasmin, cell adhesion, chemotaxis\u003cbr\u003e\nLigand\/Receptor: Urokinase plasminogen activator (uPA), vitronectin, β1, β2 and β3 integrins, kininogen\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Beaufort N, et al. 2004. J. Immunol. 172:540 2. Tarui T, et al. 2001. J. Bio. Chem. 276:3983 3. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley \u0026amp; Sons Inc, Publication\u003cbr\u003e\nGene ID: 5329\u003cbr\u003e\nUniProt: View information about CD87 on UniProt.org\u003cbr\u003e\nClone: VIM5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI MR13\u003cbr\u003e\nOther Names: Urokinase plasminogen activator-receptor, uPA-R, uPAR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864083615913,"sku":"336902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-336902","provider":"Iright","version":"1.0","type":"link"}