{"product_id":"biolegend-338801","title":"Biolegend, 338801, Purified anti-human CD44 Antibody, 25μg","description":"\u003cp\u003eCD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from a low or mid level of intensity to high expression levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Normal human PBL\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested CyTOF®, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kishimoto T, et al. eds. 1997 Leucocyte Typing VI:White Cell Differentiation Antigen. Garland Publishing Inc.\u003cbr\u003e\nProduct Citations: Rafaiee R, et al. 2023. Bioimpacts. 13:97. PubMed Leelatian N, et al. 2020. eLife. 9:e56879.. PubMed Jang G, et al. 2022. NPJ Genom Med. 7:63. PubMed Olin A, et al. 2018. Cell. 174:1277. PubMed Henrick BM, et al. 2021. Cell. . PubMed Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed Ran LJ, et al. 2018. Mol Med Rep. 18:723. PubMed\u003cbr\u003e\nRRID: AB_1501199 (BioLegend Cat. No. 338802)\u003cbr\u003e\nStructure: Variable splicing of CD44 gene generates many CD44 isoforms, 85 kD\u003cbr\u003e\nDistribution: All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells\u003cbr\u003e\nFunction: Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM\u003cbr\u003e\nLigand\/Receptor: Hyaluronan, MIP-1β, fibronectin, collagen\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, Tregs\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Haynes BF, et al. 1991. Cancer Cells 3:347. 3. Goldstein LA, et al. 1989. Cell 56:1063. 4. Mikecz K, et al. 1995. Nat. Med. 1:558.\u003cbr\u003e\nGene ID: 960\u003cbr\u003e\nUniProt: View information about CD44 on UniProt.org\u003cbr\u003e\nClone: BJ18\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VI A034\u003cbr\u003e\nOther Names: Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862909702313,"sku":"338801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-338801","provider":"Iright","version":"1.0","type":"link"}