{"product_id":"biolegend-340201","title":"Biolegend, 340201, Purified anti-human CD307d (FcRL4) Antibody, 25μg","description":"\u003cp\u003eFcRL4 (Fc receptor-like 4) is a 57 kD single pass type I transmembrane protein that exhibits 4 Ig like C2 domains. Also known as ITRA1, IGFP2, and FcRH4, FcRL4 is predominately found on a subset of memory B cells. Activation of FcRL4 contributes to B cell receptor inhibition through activation of the tyrosine kinases SHP-1 and 2. FcRL4's nascent loci is 1q23.1; however, breakpoint mutations are associated with multiple myeloma and non-Hodgkins lymphoma. Increased FcRL4 expression on memory B cells has also been observed in HIV viremic patients. FcRL4 predominately binds aggregated IgA, binds weakly with IgG3 and IgG4, and does not bind IgG1 and IgG2.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: P815 cells transfected with FcRL4\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (with relevant formats) include: immunoprecipitation and blocking. mAb 413D12 is able to block the binding of FcRL4 to aggregated IgA, IgG3, and IgG4.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Sohn HW, et al. 2011. Blood. 118:6332. PubMed Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)\u003cbr\u003e\nProduct Citations: Jourdan M, et al. 2017. PLoS One. 12(6):e0179793. PubMed\u003cbr\u003e\nRRID: AB_2231789 (BioLegend Cat. No. 340202)\u003cbr\u003e\nStructure: 57 kD, Fc receptor like, four Ig like domains\u003cbr\u003e\nDistribution: Subset of memory B cells, some multiple myeloma and non-Hodgkins lymphoma\u003cbr\u003e\nInteraction: Tyrosine phophorylated FcRL4 interacts with SHP-1, SHP-2 to inhibit the B cell receptor\u003cbr\u003e\nBioactivity: B-cell receptor inhibition\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Fc Receptors\u003cbr\u003e\nAntigen References: 1. Moir S, et al. 2008. J. Exp. Med. 205:1797. 2. Ehrhardt GRA, et al. 2003. P. Natl. Acad. Sci. USA 100:13489. 3. Ehrhardt GRA, et al. 2005. J. Exp. Med. 202:783. 4. Polson AG, et al. 2006. J. Int. Immunol. 18:1363.\u003cbr\u003e\nGene ID: 83417\u003cbr\u003e\nUniProt: View information about CD307d on UniProt.org\u003cbr\u003e\nClone: 413D12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FcRL4 (Fc receptor-like 4), IRTA1, IGFP2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862401208489,"sku":"340201","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-340201","provider":"Iright","version":"1.0","type":"link"}