{"product_id":"biolegend-340604","title":"Biolegend, 340604, PE anti-human CD300F (IREM-1) Antibody, 100tests","description":"\u003cp\u003eIREM-1 (immune receptor expressed by myeloid cell 1) is a type I single transmembrane protein encoded by human chromosome 17q24.25. A member of the CD300 (CMRF-35) family and the Ig superfamily, IREM-1 is also known as CD300F, or CD300LF (CD300-like member F). CD300F is expressed on monocytes, granulocytes, and myeloid leukemia cell lines. The cytoplasmic domain of IREM-1 contains an ITIM and associates with the P85α subunit of PI3K (phosphoinositide 3-kinase). IREM-1 also functions as an inhibitory receptor.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications include: Coengagement of IREM-1 with UP-D2 inhibits FcReI-mediated degranulation, immunoprecipitation\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690 Lee SM, et al. 2011. J. Immunol. 186:6296. PubMed.\u003cbr\u003e\nRRID: AB_2074121 (BioLegend Cat. No. 340604)\u003cbr\u003e\nStructure: Type I single transmembrane protein with cytoplamic ITIM, associates with p85α of PI3K, Ig superfamily\u003cbr\u003e\nDistribution: Monocytes, granulocytes, and myeloid leukemia cell lines\u003cbr\u003e\nFunction: Inhibition of myeloid function\u003cbr\u003e\nCell Type: Monocytes, Granulocytes, Leukemia\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Marquez JA, et al. 2007. J. Mol. Bio. 367:310 2. Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690 3. Alvarez-Errico D, et al. 2007. J. Immunol. 178:808\u003cbr\u003e\nGene ID: 146722\u003cbr\u003e\nUniProt: View information about CD300F on UniProt.org\u003cbr\u003e\nClone: UP-D2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD300LF, IREM-1, IgSF13,\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864079487145,"sku":"340604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-340604","provider":"Iright","version":"1.0","type":"link"}