{"product_id":"biolegend-342103","title":"Biolegend, 342103, PE anti-human CD82 Antibody, 25tests","description":"\u003cp\u003eCD82 is a 45-90 kD type III tetraspan membrane protein which is encoded by the KAI1 gene. A member of the 4-span transmembrane protein superfamily (TM4SF) CD82 forms a complex with CD37, CD53, CD81, ECM and MHC molecules. CD82 is expressed on monocytes, granulocytes, lymphocytes, epithelial cells, endothelial cells, and fibroblasts and plays a role in signal transduction and adhesion. It has been suggested CD82 functions as a tumor suppressor as loss of expression has been found to promote tumor metastasis.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Bertero A, et al. 2019. J Cell Biol. 218:2919. PubMed Guo D, et al. 2022. Bio Protoc. 12:. PubMed de Boer B et al. 2018. Cancer cell. 34(4):674-689 . PubMed Lambelé M, et al. 2015. J Virol. 89:3247. PubMed Kamaraj US, et al. 2020. Cell Syst. 0.811805556. PubMed Pakula A, et al. 2018. Methods Mol Biol. 1889:01:00. PubMed Andersen J, et al. 2020. Cell. 183:1913. PubMed Al Tanoury Z, et al. 2020. Development. 147:00:00. PubMed Perna F, et al. 2017. Cancer Cell. 32:506. PubMed Houtsma R, et al. 2021. STAR Protoc. 2:100864. PubMed Guo D, et al. 2022. Elife. 11:. PubMed Lathuilière A, et al. 2022. Mol Ther Methods Clin Dev. 26:441. PubMed Al Tanoury Z, et al. 2020. Development. . PubMed Lu H, et al. 2020. Am J Reprod Immunol. 83:. PubMed Plum T, et al. 2020. Immunity. 52(2):404-416. PubMed\u003cbr\u003e\nRRID: AB_1595551 (BioLegend Cat. No. 342103) AB_1595455 (BioLegend Cat. No. 342104)\u003cbr\u003e\nStructure: Type III tetraspan membrane protein, 45-90 kD, complexed with CD37, CD53, CD81, ECM and MHC molecules, 4-span transmembrane protein superfamily (TM4SF)\u003cbr\u003e\nDistribution: Monocytes, granulocytes,lymphocytes, epithelial cells, endothelial cells, fibroblasts\u003cbr\u003e\nFunction: Signal transduction, adhesion, tumor metastasis suppressor\u003cbr\u003e\nLigand\/Receptor: KITENIN\u003cbr\u003e\nCell Type: Basophils, Endothelial cells, Epithelial cells, Granulocytes, Lymphocytes, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Miranti CK. 2009. Cell. Signal. 21:196 2. Abe M, et al. 2008. 266:163 3. Lee JH et al. 2004. Cancer Res. 64:4235 4. Lagaudriere-Gesbert C, et al. 1997. J. Immunol. 158:2790\u003cbr\u003e\nGene ID: 3732\u003cbr\u003e\nUniProt: View information about CD82 on UniProt.org\u003cbr\u003e\nClone: ASL-24\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: KAI1, C33, R2, 4F9, IA4\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862542241961,"sku":"342103","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-342103","provider":"Iright","version":"1.0","type":"link"}