{"product_id":"biolegend-342608","title":"Biolegend, 342608, PE\/Cyanine7 anti-human HLA-E Antibody, 100tests","description":"\u003cp\u003eHLA-E is a non-classical MHC class I (MHC-Ib) molecule. It is characterized by limited polymorphism and ubiquitous expression. HLA-E, as other MHC-I molecules, is heterodimerized with β2-microglobulin. HLA-E interacts with CD94\/NKG2 receptor to regulate NK cell cytolysis activities.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Lee N, et al. 1998. Proc. Natl. Acad. Sci. USA. 95:5199. Wooden SL, et al. 2005. J. Immunol. 175:1383. Monaco EL, et al. 2008. J. Immunol. 181:5442. Corrah TW, et al. 2011. J. Virol. 85:3367. PubMed\u003cbr\u003e\nProduct Citations: Jo S, et al. 2022. Nat Commun. 13:3453. PubMed Steindor M, et al. 2015. PLoS One. 10:119737. PubMed Bernson E, et al. 2019. Front Immunol. 2.113888889. PubMed Grutza R, et al. 2020. J Immunol. 204:2910. PubMed Parent AV, et al. 2021. Cell Reports. 36(7):109538. PubMed\u003cbr\u003e\nRRID: AB_2565262 (BioLegend Cat. No. 342607) AB_2565263 (BioLegend Cat. No. 342608)\u003cbr\u003e\nStructure: HLA family, Ig superfamily, 42 kD\u003cbr\u003e\nDistribution: Broadly expressed\u003cbr\u003e\nFunction: Mediate cell recognition by NK cells\u003cbr\u003e\nLigand\/Receptor: CD94\/NKG2\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: 1. Sullivan LC, et al. 2008. Tissue Antigen. 72:415. 2. Koller BH, et al. 1988. J. Immunol. 141:897.\u003cbr\u003e\nGene ID: 3133\u003cbr\u003e\nUniProt: View information about HLA-E on UniProt.org\u003cbr\u003e\nClone: 3D12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: HLA class I histocompatibility antigen, alpha chain E, HLAE\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862391705769,"sku":"342608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-342608","provider":"Iright","version":"1.0","type":"link"}