{"product_id":"biolegend-342902","title":"Biolegend, 342902, Purified anti-human TCR Vα24-Jα18 (iNKT cell) Antibody, 100μg","description":"\u003cp\u003eEncoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Rhesus, Pigtailed Macaque, Sooty Mangabey\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Rout N, et al. 2010. PLoS One 5:e9787. (FC)\u003cbr\u003e\nProduct Citations: Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed Nugent JL, et al. 2021. iScience. 24:103421. PubMed Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed Speir M,et al. 2017. Sci Rep.. 10.1038\/s41598-017-14690-5. PubMed Schwabenland M, et al. 2021. Immunity. . PubMed Melo AM, et al. 2020. Cancer Immunol Immunother. 69:969. PubMed Martin E, et al. 2020. JCI Insight. :5. PubMed\u003cbr\u003e\nRRID: AB_2229301 (BioLegend Cat. No. 342902)\u003cbr\u003e\nStructure: Invariant CDR3 region of TCR Vα24-JαQ\u003cbr\u003e\nDistribution: Invariant NKT cells\u003cbr\u003e\nLigand\/Receptor: Glycolipid loaded CD1d\u003cbr\u003e\nCell Type: NKT cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: Thomas SY, et al. 2003. J. Immunol. 171:2571. Exley MA, et al. 2008. Eur. J. Immunol. 38:1756. Montoya CJ, et al. 2007. Immunology. 122:1. Gansuvd B, et al. 2003. J. Immunol. 171:2904.\u003cbr\u003e\nGene ID: 28659\u003cbr\u003e\nUniProt: View information about TCR Valpha24-Jalpha18 on UniProt.org\u003cbr\u003e\nClone: 6B11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862472413353,"sku":"342902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-342902","provider":"Iright","version":"1.0","type":"link"}