{"product_id":"biolegend-343102","title":"Biolegend, 343102, Purified anti-human CD7 Antibody, 100μg","description":"\u003cp\u003eCD7 is a 40 kD type I transmembrane glycoprotein also known as gp40. It is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL) and some acute myeloid leukemia (AML) cells. CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 costimulation can induce cytokine secretion and modulate cellular adhesion.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KG1a cell line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested PG - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported (for the relevant formats) applications include proteogenomics2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Knapp W, et al. 1989. Leucocyte Typing IV:White Cell Differentiation Antigens. Oxford University Press. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)\u003cbr\u003e\nProduct Citations: Alpert A, et al. 2022. Cell Syst. 13:71. PubMed Rodriguez L, et al. 2020. Cell Reports Medicine. 1(5):100078. PubMed Sigal N, et al. 2022. Methods Mol Biol. 2543:113. PubMed Olin A, et al. 2018. Cell. 174:1277. PubMed Baran N, et al. 2022. Nat Commun. 13:2801. PubMed Han L, et al. 2019. Haematologica. 10.3324\/haematol.2018.205534. PubMed Henrick BM, et al. 2021. Cell. . PubMed Dai Z, et al. 2022. Signal Transduct Target Ther. 7:85. PubMed Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed Sander J et al. 2017. Immunity. 47(6):1051-1066 . PubMed\u003cbr\u003e\nRRID: AB_1659214 (BioLegend Cat. No. 343102)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 40 kD\u003cbr\u003e\nDistribution: T cells, NK cells, thymocytes, hematopoietic progenitors, myeloid leukemic cell subsets\u003cbr\u003e\nFunction: T cell activation\u003cbr\u003e\nLigand\/Receptor: Cytoplasmic domain associates with P13-kinase\u003cbr\u003e\nCell Type: Hematopoietic stem and progenitors, Leukemia, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego. 2. Stillwell R, et al. 2001. Immunol. Res. 24:31. 3. Rabinowich H, et al. 1994. J. Immunol. 152:517.\u003cbr\u003e\nGene ID: 924\u003cbr\u003e\nUniProt: View information about CD7 on UniProt.org\u003cbr\u003e\nClone: CD7-6B7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: IV T-164\u003cbr\u003e\nOther Names: gp40\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862988869801,"sku":"343102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-343102","provider":"Iright","version":"1.0","type":"link"}