{"product_id":"biolegend-343304","title":"Biolegend, 343304, FITC anti-human HLA-A2 Antibody, 100tests","description":"\u003cp\u003eHLA-A2 is most common in Northern Asia and North America populations. MHC class I antigens associated with β2-microglobulin are expressed by all human nucleated cells. MHC class I molecules are involved in presentation of antigens to CD8 + T cells, playing an important role in cell-mediated immune responses and tumor surveillance.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Papain solubilized HLA-A2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: The BB7.2 antibody recognizes human leukocyte antigen (HLA) A2 which is a subset of MHC-class I molecules encoded by A*02 alleles. Additional reported applications (for the relevant formats) include: immunoprecipitation3.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Brodsky FM, et al. 1979. Immunol. Rev. 47:3. Parham P and Brodsky FM. et al. 1981. Hum. Immunol. 3:277. Lubben NB, et al. 2007. Mol Biol Cell. 18:3351. (IP)\u003cbr\u003e\nProduct Citations: Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed Xiao C, et al. 2023. Nat Aging. 3:418. PubMed Zhang H, et al. 2021. Front Immunol. 12:644520. PubMed Kim HS, et al. 2023. Bioact Mater. 21:241. PubMed Ding L, et al. 2023. J Clin Invest. 133: . PubMed Kagoya Y, et al. 2018. Nat Commun. 9:1915. PubMed Xiao C, et al. 2022. iScience. 25:103934. PubMed Dean L, et al. 2015. Forensic Sci Int. 17: 8-16. PubMed Wu W, et al. 2020. Oncol Lett. 0.91875. PubMed Kerstein A, et al. 2016. J Autoimmun. S0896-8411(16)30186-X. PubMed Qiu C, et al. 2022. Front Immunol. 12:764949. PubMed Su S, et al. 2017. Cell Res. 10.1038\/cr.2017.34. PubMed Williamson LM, et al. 2021. NPJ Precis Oncol. 5:103. PubMed Huygens C, et al. 2015. J Biol Chem. 290: 20105-20116. PubMed Meng J, et al. 2010. Clin Vaccine Immunol. 1.325694444. PubMed Morvan MG, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed Deng J, et al. 2021. J Leukoc Biol. 110:1171. PubMed Pan X, et al. 2021. Front Pharmacol. 11:539261. PubMed\u003cbr\u003e\nRRID: AB_1659246 (BioLegend Cat. No. 343303) AB_1659245 (BioLegend Cat. No. 343304)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: A*02 individuals leukocytes\u003cbr\u003e\nFunction: Antigen presentation\u003cbr\u003e\nLigand\/Receptor: CD8, CD3\/TCR\u003cbr\u003e\nCell Type: Leukocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nGene ID: 3105\u003cbr\u003e\nUniProt: View information about HLA-A2 on UniProt.org\u003cbr\u003e\nClone: BB7.2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MHC-class I\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862901182633,"sku":"343304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-343304","provider":"Iright","version":"1.0","type":"link"}