{"product_id":"biolegend-343601","title":"Biolegend, 343601, Purified anti-human CD34 Antibody, 25μg","description":"\u003cp\u003eCD34, also known as gp105-120, is a type I monomeric sialomucin-like glyco-phosphoprotein with an approximate molecular weight of 105-120 kD. It is selectively expressed on the majority of hematopoietic stem\/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue. CD34 is a commonly used marker for identifying human hematopoietic stem\/progenitor cells. Based on different sensitivities, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The 561 antibody recognizes a class III group epitope, which is resistant to sialidase\/glycolyprotease and chymopapain treatment.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Croockewit AJ, et al. 1998. Scand. J. Immunol. 47:82. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.\u003cbr\u003e\nProduct Citations: Xu C, et al. 2022. iScience. 25:105123. PubMed Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed Ortiz AM, et al. 2018. Nat Med. 24:1313. PubMed Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed Davidov T, et al. 2021. Int J Mol Sci. 22:. PubMed Ardain A, et al. 2019. Nature. 570:528. PubMed Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed Ghosh S, et al. 2019. Commun Biol. 0.325. PubMed Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed\u003cbr\u003e\nRRID: AB_1732014 (BioLegend Cat. No. 343602)\u003cbr\u003e\nStructure: 105-120 kD single chain mucin-like glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem\/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: L-selecin, E-selectin\u003cbr\u003e\nCell Type: Endothelial cells, Fibroblasts, Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 947\u003cbr\u003e\nUniProt: View information about CD34 on UniProt.org\u003cbr\u003e\nClone: 561\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gp105-120, My10, Mucosialin\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862444757161,"sku":"343601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-343601","provider":"Iright","version":"1.0","type":"link"}