{"product_id":"biolegend-343604","title":"Biolegend, 343604, FITC anti-human CD34 Antibody, 100tests","description":"\u003cp\u003eCD34, also known as gp105-120, is a type I monomeric sialomucin-like glyco-phosphoprotein with an approximate molecular weight of 105-120 kD. It is selectively expressed on the majority of hematopoietic stem\/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue. CD34 is a commonly used marker for identifying human hematopoietic stem\/progenitor cells. Based on different sensitivities, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: The 561 antibody recognizes a class III group epitope, which is resistant to sialidase\/glycolyprotease and chymopapain treatment.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Croockewit AJ, et al. 1998. Scand. J. Immunol. 47:82. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.\u003cbr\u003e\nProduct Citations: Xin Y, et al. 2021. Stem Cell Res Ther. 49:12. PubMed Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed Lu Y, et al. 2023. Sci Rep. 13:8479. PubMed Shahid AM, et al. 2022. PLoS One. 17:e0278209. PubMed Buffone A, et al. 2018. J Cell Sci. 131:. PubMed Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed Tu S, et al. 2020. Cellular Signalling. 73:109695. PubMed Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed Wu S, et al. 2020. Stem Cells Int. 2019:1515040. PubMed Xiao X, et al. 2019. Cell Discov. 5:2. PubMed Liu Z, et al. 2021. Molecules. 26:. PubMed Nathan AA, et al. 2017. Trop Med Int Health. 22:1414. PubMed BÖiers C, et al. 2018. Dev Cell. 44:362. PubMed Gao P, et al. 2017. Cytotechnology. 69:751. PubMed Arvindam US, et al. 2021. Leukemia. 35:1586. PubMed Zhang Y, et al. 2012. Int J Lower Extrem Wounds. 11:264. PubMed Oktaviono YH, et al. 2021. F1000Res. 10:15. PubMed Wang F, et al. 2021. Cell. 184(2):422-440.e17. PubMed Riding AM, et al. 2022. iScience. 25:104660. PubMed de Sousa BM, et al. 2021. NPJ Regen Med. 6:80. PubMed Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed He Z, et al. 2020. J Exp Clin Cancer Res. 39:140. PubMed Lin G, et al. 2021. Mol Med Rep. 23:. PubMed Singh A, et al. 2020. Cell Rep. 32:108153. PubMed Zhou L, et al. 2019. Exp Ther Med. 18:105. PubMed Saygin C, et al. 2021. Leukemia. 35:3406. PubMed Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed Vanoni G, et al. 2021. eLife. 10:00. PubMed Feng Y, et al. 2020. Mol Med Rep. 1.413194444. PubMed\u003cbr\u003e\nRRID: AB_1732030 (BioLegend Cat. No. 343603) AB_1732005 (BioLegend Cat. No. 343604)\u003cbr\u003e\nStructure: 105-120 kD single chain mucin-like glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem\/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: L-selecin, E-selectin\u003cbr\u003e\nCell Type: Endothelial cells, Fibroblasts, Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 947\u003cbr\u003e\nUniProt: View information about CD34 on UniProt.org\u003cbr\u003e\nClone: 561\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gp105-120, My10, Mucosialin\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862444167337,"sku":"343604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-343604","provider":"Iright","version":"1.0","type":"link"}