{"product_id":"biolegend-343605","title":"Biolegend, 343605, PE anti-human CD34 Antibody, 25tests","description":"\u003cp\u003eCD34, also known as gp105-120, is a type I monomeric sialomucin-like glyco-phosphoprotein with an approximate molecular weight of 105-120 kD. It is selectively expressed on the majority of hematopoietic stem\/progenitor cells, bone marrow stromal cells, capillary endothelial cells, embryonic fibroblasts, and some nervous tissue. CD34 is a commonly used marker for identifying human hematopoietic stem\/progenitor cells. Based on different sensitivities, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion and lymphocytes homing through binding to L-selectin and E-selectin ligands.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: The 561 antibody recognizes a class III group epitope, which is resistant to sialidase\/glycolyprotease and chymopapain treatment.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Croockewit AJ, et al. 1998. Scand. J. Immunol. 47:82. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.\u003cbr\u003e\nProduct Citations: Hu X, et al. 2023. Hematol Rep. 15:91. PubMed Che L, et al. 2023. Foods. 12:. PubMed Wang H, et al. 2023. Mol Ther Methods Clin Dev. 29:213. PubMed Liu Y, et al. 2023. Int J Stem Cells. . PubMed Shi T, et al. 2023. J Clin Invest. . PubMed Sonoda S, et al. 2022. STAR Protoc. 3:101386. PubMed Allouch A, et al. 2022. Nat Commun. 13:6739. PubMed Castañeda-Partida L, et al. 2022. Discov Oncol. 13:28. PubMed Browning D, et al. 2017. Gene Ther. 10.1038\/gt.2016.88. PubMed Gong Y, et al. 2021. Aging (Albany NY). 13:20629. PubMed Celik H, et al. 2021. Cancer Discov. 11:3126. PubMed Boutin J, et al. 2021. Nat Commun. 12:4922. PubMed Terenzi DC, et al. 2021. STAR Protoc. 2:100311. PubMed Di Stefano B, et al. 2019. Cell Stem Cell. 25:622. PubMed Woodberry T, et al. 2017. Infect Immun. 85:e00986. PubMed Yang C et al. 2019. Int J Mol Med. 43(3):1395-1405 . PubMed Besnier M, et al. 2021. Antioxidants (Basel). 10:. PubMed Jackson R, et al. 2020. Viruses. 12:00. PubMed Zhang Y, et al. 2018. Stem Cells Int. 2018:7159465. PubMed Cui D, et al. 2021. Front Cell Dev Biol. 9:656867. PubMed Cai S, et al. 2022. Cell Biosci. 12:115. PubMed Celik H, et al. 2018. Cancer Cell. 34:741. PubMed Yao X, et al. 2022. Bioeng Transl Med. 7:e10250. PubMed Longbrake EE, et al. 2018. Mult Scler. 24:728. PubMed Boulch M, et al. 2021. Sci Immunol. 6:. PubMed Yu Y, et al. 2017. Stem Cell Reports. 10.1016\/j.stemcr.2017.07.016. PubMed Niu C, et al. 2017. Mol Med Rep. 16:4879. PubMed\u003cbr\u003e\nRRID: AB_1732033 (BioLegend Cat. No. 343605) AB_1732008 (BioLegend Cat. No. 343606)\u003cbr\u003e\nStructure: 105-120 kD single chain mucin-like glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem\/progenitor cells, bone marrow stromal cells, endothelial cells, embryonic fibroblasts\u003cbr\u003e\nFunction: Cell adhesion\u003cbr\u003e\nLigand\/Receptor: L-selecin, E-selectin\u003cbr\u003e\nCell Type: Endothelial cells, Fibroblasts, Hematopoietic stem and progenitors\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 947\u003cbr\u003e\nUniProt: View information about CD34 on UniProt.org\u003cbr\u003e\nClone: 561\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gp105-120, My10, Mucosialin\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862444527785,"sku":"343605","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-343605","provider":"Iright","version":"1.0","type":"link"}