{"product_id":"biolegend-344015","title":"Biolegend, 344015, FITC anti-human CD73 (Ecto-5'-nucleotidase) Antibody, 25tests","description":"\u003cp\u003eCD73 is a 70 kD glycophosphatidylinositol (GPI)-linked 5'-nucleotidase, which is also known as ecto-5'-nucleotidase. It converts adenosine monophosphate (AMP) to adenosine. CD73 is expressed on subsets of T and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, and epithelial cells. It has been reported that CD73 costimulates T cell activation, and mediates adhesion of lymphocytes to follicular dendritic cells and endothelial cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include:immunofluorescence3. Clone AD2 has been noted to induce clustering and internalization of CD73 in vivo and inhibit metastasis in a murine breast cancer xenograft model4.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Nakamura T, et al. 1993. J. Immunol. 151:6933. Liao J, et al. 2011. J Endod. 37:1217. PubMed Touboul C, et al. 2013. J. Transl. Med. 11:28. (IF) Terp MG, et al. 2013. J Immunol. 191: 4165-73 (Block)\u003cbr\u003e\nProduct Citations: Yusa K, et al. 2016. Sci Rep. 6:29462. PubMed Lee CW, et al. 2022. J Adv Res. 39:73. PubMed Bowley TY, et al. 2022. Cancer Res Commun. 2:1436. PubMed Lu Y, et al. 2023. Sci Rep. 13:8479. PubMed Hoover MY, et al. 2023. Nat Protoc. . PubMed Huang J, et al. 2022. Clin Exp Pharmacol Physiol. 49:881. PubMed Zhang T, et al. 2022. IUBMB Life. 74:1081. PubMed Xia KS, et al. 2023. Bioact Mater. 21:69. PubMed Wang H, et al. 2022. Oxid Med Cell Longev. 2022:3082969. PubMed Tevlin R, et al. 2023. Sci Rep. 13:2097. PubMed Aru B, et al. 2023. Balkan Med J. 40:117. PubMed Chen X, et al. 2023. Exp Ther Med. 25:99. PubMed Goodnough LH, et al. 2020. JBMR Plus. 4:e10398. PubMed Liu X, et al. 2020. Exp Ther Med. 1.258333333. PubMed Tu S, et al. 2020. Cellular Signalling. 73:109695. PubMed Vishnoi M, et al. 2018. Cancer Res. 78:5349. PubMed Han J, et al. 2022. FEBS J. 289:417. PubMed Yerneni SS, et al. 2021. MBio. 12:e0165721. PubMed Morad G, et al. 2020. International Journal of Molecular Sciences. 21(11):3851. PubMed Sun W, et al. 2019. Exp Ther Med. 17:2199. PubMed Liu Y, et al. 2022. iScience. 25:104405. PubMed Gao P, et al. 2017. Cytotechnology. 69:751. PubMed Yu C, et al. 2020. Sci Rep. 10:14521. PubMed Yan K, et al. 2022. iScience. 25:104822. PubMed Ambrosi TH, et al. 2020. Aging Cell. 19:e13164. PubMed Ayhan S, et al. 2021. Journal of Cell Science. 134(6):. PubMed Keshtkar S, et al. 2021. Stem Cells Int. 8857457:2020. PubMed Ludwig N, et al. 2020. Angiogenesis. 1.374305556. PubMed Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed Aomatsu E, et al. 2014. Sci Rep. 4:3652. PubMed He Z, et al. 2020. J Exp Clin Cancer Res. 39:140. PubMed Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed Vishnoi M, et al. 2019. Mol Oncol. 13(9): 1913. PubMed Boucher JM, et al. 2018. Cardiovasc Drugs Ther. 32:519. PubMed Fei D, et al. 2021. Front Cell Dev Biol. 9:687258. PubMed Pauken CM, et al. 2021. Cancers (Basel). 13:. PubMed Zheng C, et al. 2021. J Extracell Vesicles. 10:e12109. PubMed Sprouse ML, et al. 2019. Int J Mol Sci. 20:8. PubMed\u003cbr\u003e\nRRID: AB_2561808 (BioLegend Cat. No. 344015) AB_2561809 (BioLegend Cat. No. 344016)\u003cbr\u003e\nStructure: GPI-linked 5'-nucleotidase, 70 kD\u003cbr\u003e\nDistribution: Subsets of T cells and B cells, mesenchymal stem cells, follicular dendritic cells, endothelial cells, and epithelial cells\u003cbr\u003e\nFunction: Catalyses dephosphorylation of adenosine monophosphate, costimulates T cell activation, mediates adhesion of lymphocytes to follicular dendritic cells and endothelial cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Endothelial cells, Epithelial cells, Mesenchymal Stem Cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Zola H, et al. 2007. Leukocyte and stromal Cell Molecules:the CD Markers. A John Wiley \u0026amp; Sons Inc, Publication. 2. Airas L and Jalkanen S, et al. 1996. Blood 88:1755. 3. Gutensohn W, et al. 1995. Cell Immunol. 161:213. 4. Airas L, et al. 1995. J. Exp. Med. 182:1603.\u003cbr\u003e\nGene ID: 4907\u003cbr\u003e\nUniProt: View information about CD73 on UniProt.org\u003cbr\u003e\nClone: AD2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V B-CD73.3\u003cbr\u003e\nOther Names: Ecto-5'-nucleotidase, E.C3.1.3.5, L-VAP-2, NT5E, 5'-NT\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862530248873,"sku":"344015","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-344015","provider":"Iright","version":"1.0","type":"link"}