{"product_id":"biolegend-349103","title":"Biolegend, 349103, FITC anti-human CD235a (Glycophorin A) Antibody, 25μg","description":"\u003cp\u003eCD235a (Glycophorin A) is member of the glycophorin A family. It is a type I sialoglycoprotein with a molecular weight of 10 kD, present in the cell membrane as a homodimer. Glycophorin A is expressed by erythroid precursors and erythrocytes.  It carries the antigen determinants for the MNS blood groups and has been proposed to be an inhibitor of hemagglutination and hemolysis. Glycophorin A binds siglec 5, the erythrocyte binding antigen (EBA-175) of P. falciparum and some viruses, including influenza virus and hepatitis A virus.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Mason D, et al. Eds. 2002. Leucocyte Typing VII:White Cell Differentiation Antigens. Oxford University Press. (FC)\u003cbr\u003e\nProduct Citations: Qin K, et al. 2022. Nat Genet. 54:874. PubMed Perik-Zavodskii R, et al. 2022. Genes (Basel). 13: . PubMed Abe I, et al. 2022. Dev Cell. 57:2623. PubMed Wheeler MM, et al. 2022. Nat Commun. 13:7592. PubMed Segal JM, et al. 2019. Nat Commun. 10:3350. PubMed Vinjamur DS, et al. 2021. Nat Genet. 53:719. PubMed Rao S, et al. 2021. Cell Stem Cell. 28(5):833-845.e5. PubMed Xu Y, et al. 2021. Stem Cell Res Ther. 12:112. PubMed Wu Y, et al. 2019. Nat Med. 25:776. PubMed Hurrell BP, et al. 2019. Cell Rep. 29:4509. PubMed Lan X, et al. 2020. Molecular Cell. 81(2):239-254.e8. PubMed Heatlie J, et al. 2020. Biopreserv Biobank. 1.070833333. PubMed Ruiz JP, et al. 2019. Stem Cell Res. 41:101600. PubMed Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed Zeng J, et al. 2020. Nat Med. 26:535. PubMed Martin RM et al. 2019. Cell Stem Cell. 24(5):821-828 . PubMed Shafiei-Jahani P, et al. 2021. Nat Commun. 12:2526. PubMed Lundin V, et al. 2020. Dev Cell. 446:52. PubMed Galle-Treger L, et al. 2019. Nat Commun. 10:713. PubMed Grajcarek J, et al. 2019. Nat Commun. 3.788888889. PubMed Weiss R, et al. 2021. Cells. 10:. PubMed Inglis H, et al. 2015. J Vis Exp. 97: 52484. PubMed Dinh HQ, et al. 2020. Immunity. 53(2):319-334.e6. PubMed Perik-Zavodskii R, et al. 2022. Genes (Basel). 13:. PubMed\u003cbr\u003e\nRRID: AB_10612923 (BioLegend Cat. No. 349103) AB_10613463 (BioLegend Cat. No. 349104)\u003cbr\u003e\nStructure: Member of the glycophorin A family; type I protein with a molecular weight of 10 kD; present in the membrane as homodimer\u003cbr\u003e\nDistribution: Erythrocytes and erythroid precursors\u003cbr\u003e\nFunction: Possible inhibitor of hemagglutination and hemolysis; carries the antigen determinants for the MNS blood groups\u003cbr\u003e\nLigand\/Receptor: Siglec 5, erythrocyte binding antigen (EBA-175) of P. falciparum, receptor for the influenza virus, hepatitis A virus\u003cbr\u003e\nCell Type: Erythrocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Reid ME. 2009. Immunohematology 25:95. 2. Palacajornsuk P. 2006. Immunohematology 22:171. 3. Pasvol G. 2003. Trends Parasitol. 19:430. 4. Takakuwa Y. 2001. Curr. Opin. Hematol. 8:80.\u003cbr\u003e\nGene ID: 2993\u003cbr\u003e\nUniProt: View information about CD235a on UniProt.org\u003cbr\u003e\nClone: HI264\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VII 70312\u003cbr\u003e\nOther Names: PAS-2, Sialoglycoprotein alpha, MN sialoglycoprotein, Glycophorin A, GYPA\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866456674473,"sku":"349103","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-349103","provider":"Iright","version":"1.0","type":"link"}