{"product_id":"biolegend-349106","title":"Biolegend, 349106, PE anti-human CD235a (Glycophorin A) Antibody, 100μg","description":"\u003cp\u003eCD235a (Glycophorin A) is member of the glycophorin A family. It is a type I sialoglycoprotein with a molecular weight of 10 kD, present in the cell membrane as a homodimer. Glycophorin A is expressed by erythroid precursors and erythrocytes.  It carries the antigen determinants for the MNS blood groups and has been proposed to be an inhibitor of hemagglutination and hemolysis. Glycophorin A binds siglec 5, the erythrocyte binding antigen (EBA-175) of P. falciparum and some viruses, including influenza virus and hepatitis A virus.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Mason D, et al. Eds. 2002. Leucocyte Typing VII:White Cell Differentiation Antigens. Oxford University Press. (FC)\u003cbr\u003e\nProduct Citations: Tamaoki N, et al. 2023. Cell Rep Methods. 3:100460. PubMed Calcagno DM, et al. 2020. Sci Immunol. 5: . PubMed Liao J, et al. 2023. Nat Commun. 14:207. PubMed Dickerson KM, et al. 2022. Blood Cancer Discov. 3:240. PubMed Carraro G, et al. 2021. Nat Med. 27:806. PubMed Shaham L, et al. 2015. Blood. 125:1292. PubMed Carraro G, et al. 2020. Am J Respir Crit Care Med. 202:1540. PubMed Fan X, et al. 2021. Genome Biol. 22:195. PubMed Liu S, et al. 2021. Mol Ther. 29:1918. PubMed Celik H, et al. 2021. Cancer Discov. 11:3126. PubMed Wang X, et al. 2018. Cell Death Dis. 9:578. PubMed Sakamoto S, et al. 2015. PLoS One. 10: e0139915. PubMed Rodriguez A, et al. 2021. Cell Stem Cell. 28:33. PubMed Cai J, et al. 2014. PLoS One. 9:114768. PubMed\u003cbr\u003e\nRRID: AB_10641707 (BioLegend Cat. No. 349105) AB_10640739 (BioLegend Cat. No. 349106)\u003cbr\u003e\nStructure: Member of the glycophorin A family; type I protein with a molecular weight of 10 kD; present in the membrane as homodimer\u003cbr\u003e\nDistribution: Erythrocytes and erythroid precursors\u003cbr\u003e\nFunction: Possible inhibitor of hemagglutination and hemolysis; carries the antigen determinants for the MNS blood groups\u003cbr\u003e\nLigand\/Receptor: Siglec 5, erythrocyte binding antigen (EBA-175) of P. falciparum, receptor for the influenza virus, hepatitis A virus\u003cbr\u003e\nCell Type: Erythrocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Reid ME. 2009. Immunohematology 25:95. 2. Palacajornsuk P. 2006. Immunohematology 22:171. 3. Pasvol G. 2003. Trends Parasitol. 19:430. 4. Takakuwa Y. 2001. Curr. Opin. Hematol. 8:80.\u003cbr\u003e\nGene ID: 2993\u003cbr\u003e\nUniProt: View information about CD235a on UniProt.org\u003cbr\u003e\nClone: HI264\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: VII 70312\u003cbr\u003e\nOther Names: PAS-2, Sialoglycoprotein alpha, MN sialoglycoprotein, Glycophorin A, GYPA\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866457526441,"sku":"349106","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-349106","provider":"Iright","version":"1.0","type":"link"}