{"product_id":"biolegend-349406","title":"Biolegend, 349406, PE anti-human TCR Vβ23 Antibody, 100tests","description":"\u003cp\u003eVβ23 T cell receptor (TCR Vβ23) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ + T cells. TCR α\/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Vβ23 + T cells are stimulated by the staphylococcal enterotoxin A (SEA) and by the pyrogenic toxin superantigens (PTSAgs) SpeK, SpeL, and SpeM from streptococcus.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: T-cell leukemia line HUT78\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: stimulation of HUT78 T cells to produce IL-21.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Romagne F, et al. 1995. J. Immunol. Methods 186:313. (Stim) Rebai N, et al. 1994. P. Natl. Acad. Sci. USA 91:1529. (FC) Pantaleo G, et al. 1997. P. Natl. Acad. Sci. USA 94:9848. (FC)\u003cbr\u003e\nRRID: AB_10918433 (BioLegend Cat. No. 349406)\u003cbr\u003e\nStructure: Immunoglobulin superfamily, associate with TCR Vα chain and CD3 complex\u003cbr\u003e\nDistribution: subset of TCR αβ+ T cells\u003cbr\u003e\nFunction: Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response\u003cbr\u003e\nLigand\/Receptor: MHC-peptide complex\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Guilherme L, et al. 2007. Curr. Protein Pept. Sc. 8:39. 2. Adelman MK. 2007. Crit. Rev. Immunol. 27:221. 3. Beres SB, et al. 2002. P. Natl. Acad. Sci. USA 99:10078. 4. Smoot LM, et al. 2002. Infect. Immunol. 70:7095. 5. Lavoie PM, et al. 2005. Int. Immunol. 17:931.\u003cbr\u003e\nGene ID: 6957\u003cbr\u003e\nUniProt: View information about TCR Vbeta23 on UniProt.org\u003cbr\u003e\nClone: αHUT7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell receptor Vbeta 23\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866448875689,"sku":"349406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-349406","provider":"Iright","version":"1.0","type":"link"}