{"product_id":"biolegend-350610","title":"Biolegend, 350610, PE\/Cyanine7 anti-human CD11a Antibody, 100tests","description":"\u003cp\u003eCD11a is a 170-180 kD type I transmembrane glycoprotein also known as LFA-1α chain and integrin α L subunit. CD11a non-covalently associates with integrin β 2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It is absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. CD11a\/CD18 binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: HLA-DR CTL line\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for relevant formats) include: immunoprecipitation1, 2. Note: the antibody TS2\/4 recognizes the ß-propeller domain of CD11a and only immunoprecipitates the CD11a\/CD18 complex.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Huang C and Springer TA. 1997. P. Natl. Acad. Sci. USA 94:3162. (IP) Sanchez-Madrid F, et al. 1983. J. Exp. Med. 158:1785. (IP) Sanchez-Madrid F, et al. 1982. P. Natl. Acad. Sci. USA 79:7489. (FC)\u003cbr\u003e\nRRID: AB_2728316 (BioLegend Cat. No. 350609) AB_2728317 (BioLegend Cat. No. 350610)\u003cbr\u003e\nStructure: Integrin, type I transmembrane glycoprotein, noncovalently linked with integrin β2 (CD18) forms LFA-1, 170-180 kD\u003cbr\u003e\nDistribution: Leukocytes\u003cbr\u003e\nFunction: Adhesion, costimulation\u003cbr\u003e\nLigand\/Receptor: ICAM-1(CD54), ICAM-2(CD102), ICAM-3(CD50)\u003cbr\u003e\nCell Type: Leukocytes, Tregs\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Costimulatory Molecules\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Lub M, et al. 1995. Immunol. Today 16:479. 2. Parsons J. 1996. Curr. Opin. Cell Biol. 8:146.\u003cbr\u003e\nGene ID: 3683\u003cbr\u003e\nUniProt: View information about CD11a on UniProt.org\u003cbr\u003e\nClone: TS2\/4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: V S160\u003cbr\u003e\nOther Names: LFA-1α chain, αL Integrin, Lymphocyte function-associated antigen 1, LFA-1α chain, ITGAL\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864029974697,"sku":"350610","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-350610","provider":"Iright","version":"1.0","type":"link"}