{"product_id":"biolegend-351302","title":"Biolegend, 351302, Purified anti-human CD127 (IL-7Rα) Antibody, 100μg","description":"\u003cp\u003eCD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4\/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CD127\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested PG - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported (for the relevant formats) application: proteogenomics1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)\u003cbr\u003e\nProduct Citations: Fu J et al. 2019. Cell stem cell. 24(2):227-239 . PubMed Abdel-Gadir A, et al. 2019. Nat Med. 25:1164. PubMed Mousset CM, et al. 2018. Oncoimmunology. 7:e1488565. PubMed Rouers A, et al. 2021. Cell Rep Med. 2:100278. PubMed Spoerl S, et al. 2021. Eur J Immunol. 51:1436. PubMed Alpert A, et al. 2022. Cell Syst. 13:71. PubMed Leader AM, et al. 2021. Cancer Cell. 39:1594. PubMed Glass MC, et al. 2022. Cell Rep. 39:110728. PubMed McCarthy EE, et al. 2022. Cell Rep. 39:110815. PubMed Poon MML, et al. 2023. Nat Immunol. 24:309. PubMed Alroqi F, et al. 2017. J Clin Immunol. . 10.1007\/s10875-017-0451-1. PubMed Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed Fan J, et al. 2019. Nat Commun. 1.984027778. PubMed Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed Li Y, et al. 2019. Front Immunol. 0.460416667. PubMed Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed Oba T, et al. 2021. J Immunother Cancer. 9:. PubMed Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed Michlmayr D, et al. 2020. Cell Reports. 31(4):107569. PubMed Cobb DA, et al. 2022. J Immunother Cancer. 10:. PubMed Tripathi T, et al. 2019. Immunohorizons. 0.201388889. PubMed Lundtoft C, et al. 2017. PLoS Pathogens. 13(6):e1006425. PubMed Chng MHY, et al. 2020. Immunity. 51(6):1119-1135.e5.. PubMed Cardoso V, et al. 2017. Nature. 549:277. PubMed Mishra A, et al. 2021. Cell. 184(13):3394-3409.e20. PubMed Schwabenland M, et al. 2021. Immunity. . PubMed NULL, et al. 2022. Cell. 185:916. PubMed Dinh HQ, et al. 2020. Immunity. 53(2):319-334.e6. PubMed Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed\u003cbr\u003e\nRRID: AB_10718513 (BioLegend Cat. No. 351302)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, associates with CD132, 60-90 kD\u003cbr\u003e\nDistribution: Immature B cells through early pre-B stage, thymocytes (except CD4\/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells\u003cbr\u003e\nFunction: T cell and immature B cell proliferation and development\u003cbr\u003e\nLigand\/Receptor: IL-7\u003cbr\u003e\nCell Type: B cells, T cells, Thymocytes, Tregs\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125. 2. He YW and Malek TR. 1998. Crit. Rev. Immunol. 18:503. 3. Huster KM, et al. 2004. P. Natl. Acad. Sci. USA 101:5610. 4. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403. 5. Morrissey PJ, et al. 1989. J. Exp. Med. 169:707. 6. Liu W, et al. 2006. J. Exp. Med. 203:1701.\u003cbr\u003e\nGene ID: 3575\u003cbr\u003e\nUniProt: View information about CD127 on UniProt.org\u003cbr\u003e\nClone: A019D5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-7 receptor α chain, IL-7Rα\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864382558377,"sku":"351302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-351302","provider":"Iright","version":"1.0","type":"link"}