{"product_id":"biolegend-351806","title":"Biolegend, 351806, PE anti-human CD221 (IGF-1R) Antibody, 100tests","description":"\u003cp\u003eCD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1\/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: IGF-1 receptor purified from human placentas\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: This clone has been published as 1H7. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining of frozen tissue sections2, and blocking functions2-5.This product is offered for sale and sold pursuant to a license to seller by City of Hope and may be used only as a research reagent. Use for any other purpose is expressly not authorized.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Li SL, et al. 1993. Biochem. Bioph. Res. Co. 196:92. (WB IP) Li SL, et al. 2000. Cancer Immunol. Immun. 49:243. (IHC Block) Ye JJ, et al. 2003. Horm. Metab. Res. 35:836. (Block) Kusada Y, et al. 2008. J. Biochem. 143:9. (Block) Ohtani M, et al. 2009. Biosci. Trends. 3:131. (Block)\u003cbr\u003e\nProduct Citations: Bitton A, et al. 2021. Cytometry A. . PubMed Pasternack J, et al. 2014. J Nucl Med. 55:2012. PubMed\u003cbr\u003e\nRRID: AB_10900986 (BioLegend Cat. No. 351805) AB_10895918 (BioLegend Cat. No. 351806)\u003cbr\u003e\nStructure: IGF-1R contains 2 α subunits and 2 β subunits, 135 kD\u003cbr\u003e\nDistribution: Haematopoietic cells and non-haematopoietic cells\u003cbr\u003e\nFunction: Cell growth and immune cells recruitment\u003cbr\u003e\nLigand\/Receptor: IGF-1, IGF-2\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Baudler S, et al. 2005. J. Immunol. 174:5516. 2. Sharp LL, et al. 2005. Nat. Immunol. 6:73.\u003cbr\u003e\nGene ID: 3480\u003cbr\u003e\nUniProt: View information about CD221 on UniProt.org\u003cbr\u003e\nClone: 1H7\/CD221\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Insulin-like growth factor 1 receptor (IGF1R)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860861735081,"sku":"351806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-351806","provider":"Iright","version":"1.0","type":"link"}