{"product_id":"biolegend-352807","title":"Biolegend, 352807, Biotin anti-human CD126 (IL-6Rα) Antibody, 25μg","description":"\u003cp\u003eCD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain\/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: African Green, Baboon, Cynomolgus, Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human myeloma cell line U266\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Huang YW and Vitetta ES. 1993. Hybridoma 12:621.\u003cbr\u003e\nRRID: AB_11203528 (BioLegend Cat. No. 352808)\u003cbr\u003e\nStructure: Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD\u003cbr\u003e\nDistribution: Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts\u003cbr\u003e\nFunction: Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation\u003cbr\u003e\nInteraction: CD130, c-Src, STAT3, WWP1, WWP2\u003cbr\u003e\nLigand\/Receptor: IL-6\u003cbr\u003e\nCell Type: B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797. 2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London. 3. Boulanger MJ, et al. 2003. Science 300:2101. 4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820.\u003cbr\u003e\nGene ID: 3570\u003cbr\u003e\nUniProt: View information about CD126 on UniProt.org\u003cbr\u003e\nClone: UV4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-6R1, gp80, IL-6 receptor alpha, IL-6R\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864080797865,"sku":"352807","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-352807","provider":"Iright","version":"1.0","type":"link"}