{"product_id":"biolegend-353310","title":"Biolegend, 353310, FITC anti-human Perforin Antibody, 100tests","description":"\u003cp\u003ePerforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracelluar immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nProduct Citations: Li D, et al. 2023. Int J Oncol. 62:. PubMed Muralidhar A, et al. 2024. J Immunother Cancer. :12. PubMed Harari A, et al. 2021. Cancers (Basel). 13:. PubMed Chen M, et al. 2021. Cancers (Basel). 13:. PubMed Cohen KW, et al. 2021. Cell Reports Medicine. 2(7):100354. PubMed Garcia-Valtanen P, et al. 2022. Cell Rep Med. 3:100651. PubMed Graciotti M, et al. 2020. Vaccines (Basel). 8:00. PubMed\u003cbr\u003e\nRRID: AB_2571966 (BioLegend Cat. No. 353309) AB_2571967 (BioLegend Cat. No. 353310)\u003cbr\u003e\nStructure: 70 kD\u003cbr\u003e\nDistribution: CTL, NK (cytoplasmic granules)\u003cbr\u003e\nFunction: Mediates targeted cell lysis.\u003cbr\u003e\nCell Type: NK cells, T cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Lieberman J. 2003. Nat. Rev. Immunol. 3:361. 2. Trapani J, et al. 2002. Nat. Rev. Immunol. 2:735.\u003cbr\u003e\nGene ID: 5551\u003cbr\u003e\nUniProt: View information about Perforin on UniProt.org\u003cbr\u003e\nClone: B-D48\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PRF1, P1, PFP, HPLH2\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866451071145,"sku":"353310","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-353310","provider":"Iright","version":"1.0","type":"link"}