{"product_id":"biolegend-354211","title":"Biolegend, 354211, Brilliant Violet 421™ anti-human CD303 (BDCA-2) Antibody, 25tests","description":"\u003cp\u003eCD303, also known as BDCA-2 and CLEC4C, is a 38 kD type II transmembrane glycoprotein. It is a member of the C-type lectin superfamily. CD303 is expressed by plasmacytoid dendritic cells (pDCs) and is involved in cell adhesion, signaling, and antigen capture and processing. Crosslinking of CD303 inhibits the production of IFN-α\/β and TLR-9 induced pDCs maturation.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Freeman A, et al. 2014. PLoS One. 9:110928. PubMed Johnson P, et al. 2015. Clin Cnacer Res. 21:1321. PubMed\u003cbr\u003e\nProduct Citations: Ribeiro MS, et al. 2023. Methods Mol Biol. 2618:289. PubMed Perry JSA, et al. 2018. Immunity. 48:923. PubMed Izmirly AM, et al. 2022. PLoS Pathog. 18:e1009903. PubMed Chen YL, et al. 2020. J Exp Med. 217:. PubMed Connors J, et al. 2022. Geroscience. :. PubMed\u003cbr\u003e\nRRID: AB_2562320 (BioLegend Cat. No. 354211) AB_2563871 (BioLegend Cat. No. 354212)\u003cbr\u003e\nStructure: Type II transmembrane protein, 38 kD, member of the C-type lectin superfamily\u003cbr\u003e\nDistribution: Plasmacytoid dendritic cells\u003cbr\u003e\nFunction: Antigen capture, inhibition of IFN α\/β production\u003cbr\u003e\nCell Type: Dendritic cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Jähn PS, et al. 2010. Cell Immunol. 265:15. 2. Graham LM and Brown GD. 2009. Cytokine 48:148. 3. Röck J, et al. 2007. Eur. J. Immunol. 37:3564. 4. Dzionek A, et al. 2001. J. Exp. Med. 194:1823.\u003cbr\u003e\nGene ID: 170482\u003cbr\u003e\nUniProt: View information about CD303 on UniProt.org\u003cbr\u003e\nClone: 201A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC4C, CLECSF11, CLECSF7, DLEC, HECL\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860866912425,"sku":"354211","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-354211","provider":"Iright","version":"1.0","type":"link"}