{"product_id":"biolegend-354503","title":"Biolegend, 354503, PE anti-human CD304 (Neuropilin-1) Antibody, 25tests","description":"\u003cp\u003eCD304, also known as neuropilin-1, BDCA-4 and VEGF165R, is a 140 kD type I transmembrane protein. Its extracellular region contains 2 CUB, 2 FV\/FVIII, and one MAM domain; a soluble isoform is produced by alternative mRNA splicing. CD304 is involved in angiogenesis, neural development, and tumor metastasis. It's expressed by plasmacytoid dendritic cells, thymocytes, neurons, endothelium, and a subset of T FH cells. CD304 is also expressed in several carcinomas, and a high expression of this molecule in prostate cancer correlates with a poor prognosis.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: CD304-Fc Fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Soday L, et al. 2021. Frontiers in Immunology. 12:600056. PubMed Cignarella F et al. 2018. Cell metabolism. 27(6):1222-1235 . PubMed Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed Tandon S, et al. 2022. Br J Haematol. 196:e34. PubMed Combes AJ, et al. 2022. Cell. 185:184. PubMed Kitai H, et al. 2022. BMC Biol. 20:248. PubMed Leclerc M, et al. 2019. Nat Commun. 10:3345. PubMed Cillo AR, et al. 2021. Cell Rep Med. 2:100476. PubMed Mujal AM, et al. 2022. Cancer Immunol Res. 10:403. PubMed Congy-Jolivet N, et al. 2022. EBioMedicine. 80:104047. PubMed Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed\u003cbr\u003e\nRRID: AB_11219200 (BioLegend Cat. No. 354503) AB_11219194 (BioLegend Cat. No. 354504)\u003cbr\u003e\nStructure: Type I transmembrane protein, 140 kD, 2 complement binding domains (CUB), 2 coagulation factor V\/VIII homology domains (FV\/FVIII), one meprin, A5, receptor tyrosine phosphatase domain (MAM)\u003cbr\u003e\nDistribution: Plasmacytoid dendritic cells, thymocytes, subset of follicular helper T cells (TFH), endothelial cells, neurons, some carcinomas\u003cbr\u003e\nFunction: Angiogenesis, neuronal development, tumor metastasis\u003cbr\u003e\nLigand\/Receptor: VEGF165, semaphorin-3A\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Neurons, Tfh, Thymocytes\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Mizui M and Kikutani H. 2008. Immunity 28:302. 2. Hamerlik P, et al. 2012. J. Exp. Med. 209:507. 3. Karjalainen K, et al. 2011. Blood 117:920. 4. Lepelletier Y, et al. 2007. P. Natl. Acad. Sci. USA 104:5545.\u003cbr\u003e\nGene ID: 8829\u003cbr\u003e\nUniProt: View information about CD304 on UniProt.org\u003cbr\u003e\nClone: 12C2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BDCA-4\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864327868585,"sku":"354503","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-354503","provider":"Iright","version":"1.0","type":"link"}