{"product_id":"biolegend-354607","title":"Biolegend, 354607, Brilliant Violet 421™ anti-human CD290 (TLR10) Antibody, 25tests","description":"\u003cp\u003eCD290, also known as TLR10, is a 91-100 kD glycosylated protein belonging to the toll-like receptor family. It is expressed on B cell, Treg cells, and plasmacytoid dendritic cells but absent on T cells, particularly non-Treg and granulocytes. It can interact with MyD88 and plays an important role in innate immunity and pattern recognition.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified extracellular domain of human TLR10 (amino acids 20-474) (NP_001017388 )\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450\/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Guan Y, et al. 2010. J. Immunol. 184:5094.\u003cbr\u003e\nRRID: AB_3662263 (BioLegend Cat. No. 354607) AB_3662263 (BioLegend Cat. No. 354608)\u003cbr\u003e\nStructure: Member of the toll-like receptor family, type I membrane protein, 91-100 kD\u003cbr\u003e\nDistribution: B cells, Treg cells, plasmacytoid DCs\u003cbr\u003e\nFunction: Interacts with MyD88 and TRAF6, which results in NF-kB activation and cytokine secretion\u003cbr\u003e\nLigand\/Receptor: MyD88 and TRAF6\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Tregs\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: 1. Chuang T, et al. 2001. Biochim. Biophys. Acta. 1518:157. 2. Hornung V, et al. 2002. J. Immunol. 168:4531. 3. Bourke E, et al. 2003. Blood 102:956.\u003cbr\u003e\nGene ID: 81793\u003cbr\u003e\nUniProt: View information about CD290 on UniProt.org\u003cbr\u003e\nClone: 3C10C5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Toll like receptor 10\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What is the F\/P ratio range of our BV421™ format antibody reagents?\u003cbr\u003e\nA: It is lot-specific. On average it ranges between 2-4.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862389215401,"sku":"354607","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-354607","provider":"Iright","version":"1.0","type":"link"}