{"product_id":"biolegend-355005","title":"Biolegend, 355005, APC anti-human CD124 (IL-4Rα) Antibody, 25tests","description":"\u003cp\u003eCD124, also known as the alpha subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13.  A truncated form of IL-4Rα exists in the soluble form in biological fluids. CD124 is expressed on human B and T cells as well as a variety of other hematopoietic and non-hematopoietic cells and cell lines.  In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R\/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R\/IL-13Ra1) is the main route for non-hematopoietic cell responses to IL-4 or IL-13.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human IL-4Rα Fc chimera\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed Miek L, et al. 2022. Immunology. 166:47. PubMed Lee J, et al. 2017. PLoS One.. 10.1371\/journal.pone.0183594. PubMed Bi CS, et al. 2020. Cell Prolif. 53:e12827. PubMed Grabosch S, et al. 2017. Gynecologic Oncology. 10.1016\/j.ygyno.2017.04.008. PubMed\u003cbr\u003e\nRRID: AB_2562506 (BioLegend Cat. No. 355005) AB_2562507 (BioLegend Cat. No. 355006)\u003cbr\u003e\nStructure: 140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit\u003cbr\u003e\nDistribution: B cells, T cells, endothelial cells, cancer cells\u003cbr\u003e\nFunction: Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells\u003cbr\u003e\nInteraction: STAT6\u003cbr\u003e\nLigand\/Receptor: IL-4, IL-13\u003cbr\u003e\nCell Type: B cells, Endothelial cells, T cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Kashiwada M, et al. 2001. J. Immunol. 167:6382. Gilmour J, et al. 2008. Immunology 124:437. Hage T, et al. 1999. Cell 97:271.\u003cbr\u003e\nGene ID: 3566\u003cbr\u003e\nUniProt: View information about CD124 on UniProt.org\u003cbr\u003e\nClone: G077F6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-4 receptor α subunit\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866099798185,"sku":"355005","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-355005","provider":"Iright","version":"1.0","type":"link"}