{"product_id":"biolegend-355106","title":"Biolegend, 355106, FITC anti-human CD70 Antibody, 100tests","description":"\u003cp\u003eCD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. CD70 costimulates T cell proliferation and differentiation. It plays a role in the pDC-induced B cell differentiation. The ligand of CD70 is CD27.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: CD70-transfected L cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Shaw J, et al. 2010. Blood 115:3051. (Block)\u003cbr\u003e\nProduct Citations: Wang S, et al. 2020. Cell Rep. 969:30. PubMed Perna F, et al. 2017. Cancer Cell. 32:506. PubMed\u003cbr\u003e\nRRID: AB_2562278 (BioLegend Cat. No. 355105) AB_2562280 (BioLegend Cat. No. 355106)\u003cbr\u003e\nStructure: Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas\u003cbr\u003e\nFunction: Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation\u003cbr\u003e\nLigand\/Receptor: CD27\u003cbr\u003e\nCell Type: B cells, Dendritic cells, NK cells, T cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Bowman MR, et al. 1994. J. Immunol. 152:1756. 2. Shaw J, et al. 2010. Blood 115:3051. 3. Keller AM, et al. 2009. Blood 113:5167.\u003cbr\u003e\nGene ID: 970\u003cbr\u003e\nUniProt: View information about CD70 on UniProt.org\u003cbr\u003e\nClone: 113-16\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860786892969,"sku":"355106","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-355106","provider":"Iright","version":"1.0","type":"link"}