{"product_id":"biolegend-357508","title":"Biolegend, 357508, PE\/Cyanine7 anti-human CD269 (BCMA) Antibody, 100tests","description":"\u003cp\u003eCD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single pass transmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a B cell maturation factor, essential for the long-term survival of plasma cells. It is expressed by plasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF and APRIL, and its cytoplasmic domain binds several of the TRAF family members.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: BCMA-mouse IgG Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Ramkumar P, et al. 2020. Blood Adv. 2.179861111. PubMed Alhaj Hussen K, et al. 2017. Immunity. 47:680. PubMed Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed\u003cbr\u003e\nRRID: AB_2566526 (BioLegend Cat. No. 357507) AB_2566527 (BioLegend Cat. No. 357508)\u003cbr\u003e\nStructure: Single pass transmembrane protein, member of the TNFR superfamily, 1 TNFR-Cys domain, 27 kD\u003cbr\u003e\nDistribution: Plasmablasts, plasma cells, germinal center B cells\u003cbr\u003e\nFunction: B cell maturation factor, essential for survival of plasma cells\u003cbr\u003e\nInteraction: Associates with several TRAF family members\u003cbr\u003e\nLigand\/Receptor: BAFF, APRIL\u003cbr\u003e\nCell Type: B cells, Plasma cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Coquery CM and Erickson LD. 2012. Crit. Rev. Immunol. 32:287. 2. Notas G, et al. 2012. J. Immunol. 189:4748. 3. Rickert RC, et al. 2011. Immunol. Rev. 244:115. 4. Mesin L, et al. 2011. J. Immunol. 187:2867.\u003cbr\u003e\nGene ID: 608\u003cbr\u003e\nUniProt: View information about CD269 on UniProt.org\u003cbr\u003e\nClone: 19F2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BCM, TNFRSF17\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860831031465,"sku":"357508","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-357508","provider":"Iright","version":"1.0","type":"link"}