{"product_id":"biolegend-357816","title":"Biolegend, 357816, Biotin anti-human ROR1 Antibody, 100μg","description":"\u003cp\u003eROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone 2A2 binds to the membrane distal Ig-domain of ROR1. Clone 2A2 has also been shown to exhibit cross reactivity towards mouse ROR12.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Dave H, et al. 2012. PLoS One 7:e52655. (FC) Baskar S, et al. 2012. MAbs. 4:349. (FC)\u003cbr\u003e\nRRID: AB_2715938 (BioLegend Cat. No. 357816)\u003cbr\u003e\nStructure: Type I transmembrane protein, consist of 1 frizzled domain, 1 Ig-like C2-type domain, 1 kringle domain, and 1 non-functional kinase domain; member of the ROR subfamily of surface receptors\u003cbr\u003e\nDistribution: Embryonic tissue, central nervous system, chronic lymphocytic leukemia cells\u003cbr\u003e\nLigand\/Receptor: Wnt5a\u003cbr\u003e\nCell Type: Embryonic Stem Cells, Leukemia\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nAntigen References: Bicocca VT, et al. 2012. Cancer Cell. 22:656. Zhang S, et al. 2012. PLoS One 7:e31127. Uhrmacher S, et al. 2011. Leuk Res. 35:1360. Yang J, et al. 2011. PLoS One 6:e21018. Grumolato L, et al. 2010. Genes Dev. 24:2517.\u003cbr\u003e\nGene ID: 4919\u003cbr\u003e\nUniProt: View information about ROR1 on UniProt.org\u003cbr\u003e\nClone: 2A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Receptor tyrosine kinase-like orphan receptor 1, Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase receptor-related 1, NTRKR1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866551439529,"sku":"357816","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-357816","provider":"Iright","version":"1.0","type":"link"}