{"product_id":"biolegend-358205","title":"Biolegend, 358205, PE\/Cyanine7 anti-human GPR56 Antibody, 25tests","description":"\u003cp\u003eGPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids.  GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human GPR56-mouse Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone CG4 cross-reacts with mouse1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Rao TN, et al. 2015. Stem Cell Res. 14:307. (FC) PubMed\u003cbr\u003e\nProduct Citations: Wanjalla CN, et al. 2021. Cell Reports Medicine. 2(2):100205. PubMed Wanjalla CN, et al. 2019. Front Immunol. 10:408. PubMed Tomellini E, et al. 2020. Cell Reports. 28(4):1063-1073.e5.. PubMed Mysore V, et al. 2021. Med (N Y). 2:1050. PubMed\u003cbr\u003e\nRRID: AB_2562089 (BioLegend Cat. No. 358205) AB_2562090 (BioLegend Cat. No. 358206)\u003cbr\u003e\nStructure: Contains seven transmembrane domains and a mucin-like domain in the N-terminal region\u003cbr\u003e\nDistribution: T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart\u003cbr\u003e\nFunction: May be involved in immune cell migration, cancer cell growth metastasis, and neuron development\u003cbr\u003e\nCell Type: NK cells, T cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: 1. Peng YM, et al. 2011. J. Leukoc. Biol. 90:735. 2. Shashidhar S, et al. 2005. Oncogene 24:1673. 3. Piao X, et al. 2004. Science 303:2033. 4. Liu M, et al. 1999. Genomics 55:296.\u003cbr\u003e\nGene ID: 9289\u003cbr\u003e\nUniProt: View information about GPR56 on UniProt.org\u003cbr\u003e\nClone: CG4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TM7XN1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862991491241,"sku":"358205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-358205","provider":"Iright","version":"1.0","type":"link"}