{"product_id":"biolegend-358410","title":"Biolegend, 358410, Biotin anti-human CD120b Antibody, 500μg","description":"\u003cp\u003eCD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial CD120b recombinant protein expressed in 293E cells (22-211aa).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2564394 (BioLegend Cat. No. 358410)\u003cbr\u003e\nStructure: 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI\u003cbr\u003e\nDistribution: Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes\u003cbr\u003e\nFunction: When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 that possess ubiquitin ligase activity; cysteine rich extracellular region\u003cbr\u003e\nInteraction: Interacts with TTRAP and TRAF2\u003cbr\u003e\nLigand\/Receptor: TNF-α and TNF-β (LT-α)\u003cbr\u003e\nCell Type: Granulocytes, Lymphocytes, Monocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Andrews JS, et al. 1990. J. Immunol. 144:2582. 2. Nophar Y, et al. 1990. EMBO J. 9:3269. 3. Kohno T, et al. 1990. Proc. Natl. Acad. Sci. USA 87:8331. 4. Tartaglia LA, et al. 1991. Proc. Natl. Acad. Sci. USA 88:9292. 5. Hijdra D, et al. 2012. J. Inflamm. (Lond). 9:38. 6. Chen X, et al. 2013. J. Immunol. 190:1076.\u003cbr\u003e\nGene ID: 7133\u003cbr\u003e\nUniProt: View information about CD120b on UniProt.org\u003cbr\u003e\nClone: 3G7A02\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864372531369,"sku":"358410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-358410","provider":"Iright","version":"1.0","type":"link"}