{"product_id":"biolegend-359806","title":"Biolegend, 359806, PE anti-human CD41\/CD61 Antibody, 100tests","description":"\u003cp\u003eCD41\/CD61, also known as gpIIb\/IIIa, is a member of a family integrin receptors. This is a complex comprised by CD41 and CD61 through non-covalent association. CD41\/CD61 is mainly expressed by platelets and megakaryocytes. The resting form of the CD41\/CD61 complex is involved in platelet activation and aggregation by binding to immobilized fibrinogen. After activation, CD41\/CD61 becomes a receptor for soluble fibrinogen and several other RGD-containing adhesive proteins such as von Willebrand Factor (vWF) and fibronectin. An absence or dysfunction of CD41\/CD61 on the platelet surface results in an inherited bleeding disorder, called Glanzmann Thromsasthenia (GT). CD41\/CD61 has been found on murine hematopoietic progenitor cells, indicating that this complex may play a role in regulating hematopoietic development.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human platelets\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for relevant formats) include: immunoprecipitation1 and blocking (aggregation)2. The Ultra-LEAF™ purified antibody (Endotoxin \u0026lt;0.01 EU\/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 359804). A2A9\/6 is recognized as having high affinity to gpIIb\/IIIa. It has been shown to inhibit platelet aggregation induced by a variety of agonists and the initiation of clot formation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Basani RB, et al. 1996. Blood. 88:167. (IP) Bennett JS, et al. 1983. Proc. Natl. Acad. Sci. USA. 80:2417. (Block)\u003cbr\u003e\nProduct Citations: Banka AL, et al. 2023. Nat Commun. 14:2462. PubMed Slingsby MHL, et al. 2021. Haematologica. Online ahead of print. PubMed Marsden AJ, et al. 2021. ACS Pharmacol Transl Sci. 4:1567. PubMed\u003cbr\u003e\nRRID: AB_2562700 (BioLegend Cat. No. 359805) AB_2562701 (BioLegend Cat. No. 359806)\u003cbr\u003e\nStructure: Complex of CD41 and CD61 through non-covalent association.\u003cbr\u003e\nDistribution: Platelets and megakaryocytes.\u003cbr\u003e\nFunction: Mediates attachment to cells of diverse matrix proteins.\u003cbr\u003e\nLigand\/Receptor: Fibrinogen, RGD-containing adhesive proteins such as vonWillebrand Factor (vWF) and fibronectin.\u003cbr\u003e\nCell Type: Megakaryocytes, Platelets\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: 1. Matsumura-Takeda K, et al. 2007. Stem Cell. 25:862. 2. Corbel C, et al. 2005. 49:279. 3. Bennett JS, et al. 1983. Proc. Natl. Acad. Sci. USA. 80:2417. 4. Clemetson KJ, et al. 1994. Curr. Opin. Hematol. 1:388.\u003cbr\u003e\nGene ID: 36903674\u003cbr\u003e\nUniProt: View information about CD41 or CD61 on UniProt.org\u003cbr\u003e\nClone: A2A9\/6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: gpIIb\/gpIIIa\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862521565353,"sku":"359806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-359806","provider":"Iright","version":"1.0","type":"link"}